W. Kline Bolton, MD, FASN

W. Kline Bolton, MD, FASN

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Professor of Medicine

MD: University of Virginia
Residency: Boston City Hospital, Harvard Medical School
Fellowship: Pritzker School of Medicine
Certification: Internal Medicine, Nephrology

434-924-5125 | Fax 434-924-5848 | wkb5s@virginia.edu

My interests are in the areas of molecular dissection of the epitopes involved in Goodpasture's syndrome, the role of T regulatory cells in disease modification, and in chronic kidney disease (CKD). My experimental work involves a rat model of Goodpasture's disease which can be induced with a single peptide which induces intra- and intermolecular epitope spreading on GBM antigens. I am involved in clinical trials to slow progression of kidney disease, prevent complications of CKD, and better prepare patients for renal replacement therapy.

My professional activities include:  involvement in numerous Clinical Practice Guideline work groups in kidney diseases; serving as a Board member of the Renal Physicians Association (RPA) which is dedicated to improving the quality of the clinical practice of Nephrology, and chairing the Clinical Practice Committee of the RPA; and participating in numerous activities in the American Society of Nephrology and the National Kidney Foundation.


References
PubMed Search for articles by faculty member »

West A, Bellizzi B, Bolton WK. A case of being "double positive". Submitted, Chief Resident Clinical Medicine Conference. UVA J Med. 2009;Dec 6:31-37.

Fishbane S, Bolton WK, Adeera L, Wolfgang C, Winkelmayer MD, Brenner RM, Zhu L, Lynn M, Pereria B. Factors associated with the hemoglobin response to ferumoxytol as an intravenous iron replacement therapy in CKS patients not on dialysis. Kidney Int. Submitted.

Abdel-Kader K, Patel P, Kallen A, Cochran-Sinkowitz R, Bolton WK, Unruh ML. Nephrogenic systemic fibrosis: a survey of nephrologists' beliefs, attitudes, and practices. CJSAN. In press, 2010.

Turgut F, Bolton WK. Potential new therapeutic agents for diabetic kidney disease. Submitted, 2009.

Sung SS, Bolton WK. T cells and dendritic cells in glomerular disease: the new glomerulotubular feedback loop. Kidney Int. Dec. 23, 2009, Epub ahead of print pp1-7.

Rosner MH, Bolton WK. Ferumoxytol for the treatment of anemia in chronic kidney disease. Drugs of Today. 2009;45:779-786.

Rosner MH, Bolton WK. Drug profile of Ferumoxytol. Exp Rev Hematol. In press, 2009.

Bolton WK. Pulmonary renal syndrome and emergency therapy. Cardiorenal syndromes in critical care. CMP. 2010;165:166-173.

Bolton WK. Pulmonary renal syndrome and emergency therapy. S. Karger AG, Basel. In press, 2010.

Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J Am Soc Nephrol. 2006;17(11):3076-3081.

Bolton WK, Chen L, Hellmark T, Wieslander J, Fox JW. Epitope Spreading and Autoimmune Glomerulonephritis in Rats Induced by a T-cell Epitope of Goodpasture's Antigen. J Am Soc Nephrol. 2005;16(9):2657-2666.

Chen L, Hellmark T, Wieslander J, Bolton WK. Immunodominant epitopes of a3(IV)NC1 induce autoimmune glomerulonephritis in rats. Kidney Int. 2003;64(6):2108-2120.

Hellmark T, Chen L, Ohlsson S, Wieslander J, Bolton WK. Point mutations of single amino acids abolish ability of a3 NC1 domain to elicit experimental autoimmune glomerulonephritis in rats. J Biol Chem. 2003;278(47):46516-46522.

Luo AM, Fox JW, Chen L, Bolton WK. Synthetic peptides of Goodpasture's antigen in anti-glomerular basement membrane nephritis in rats. J Lab Clin Med. 2002;139(5):303-310.