Amandeep Bajwa, PhD
Assistant Professor of Medicine
434-924-2110 | Fax 434-924-5848 | email@example.com
The primary focus of research is to investigate the role of sphingolipid receptors (Sphingosine-1-Phosphate-1/3, S1P1 or S1P3) in kidney transplantation. To further explore the role of S1P1 and S1P3 on dendritic cells (DCs) in context of immune dependent transplant rejection (acute rejection). Our work suggests the lack of S1P3s on DCs prolongs graft survival due to the inability of DCs to mature to an inflammatory/danger response. The long term goal is to evaluate the role of S1P receptors and kinases mechanisms as related to transplantation - in context of adaptive immune response in acute and chronic transplantation rejection.
Bajwa A, Kinsey GR, Okusa MD. Immune Mechanisms and Novel Pharmacological Therapies of Acute Kidney Injury. Curr Drug Targets. 2009; 10:1196-1204.
Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Proximal Tubule Sphingosine-1-Phosphate 1 Receptor Activation Protects Against Kidney Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2010 Mar; 21: 955-965.
Lobo PI, Bajwa A, Schlegel KH, Vengal J, Lee SJ, Huang L, Ye H, Deshmukh U, Wang T, Pei H, Okusa MD. Natural IgM Anti-Leukocyte Autoantibodies Attenuate Excess Inflammation Mediated by Innate and Adaptive Immune Mechanisms Involving Th-17. J Immunol. 2012 Feb 15; 188(4):1675-85 and JI cover.
Bajwa A, Huang L, Ye H, Dondeti K, Song S, Roisn DL, Lynch LR, Lobo PI, Li L, and Okusa MD. Dendritic Cell Sphingosine 1-Phosphate Receptor-3 Regulates Th1-Th2 Polarity in Kidney Ischemia-Reperfusion Injury. J Immunol. 2012; 189(5).