Peter I. Lobo, MD
Professor of Medicine
MD: Makerere University, Uganda
434-924-5125 | Fax 434-924-5848 | email@example.com
My basic research involves investigating the role of naturally occurring IgM autoantibodies that bind to receptors on inflammatory cells and endothelial cells. Thus far, we have shown that these antibodies regulate inflammatory cell functions and downregulate the inflammatory response that occurs after acute ischemic injury to the kidney, as well as after transplantation (i.e. rejection). A subset of normal individuals and patients awaiting transplantation (i.e. kidney, heart) have high levels of these natural antibodies. We and others have noted a strong association between the presence of high IgM anti-leukocyte natural antibodies and protection from rejection.
Currently, our basic research efforts are focused on 1) studying the mechanism by which IgM downregulates the inflammatory response; 2) determining if there is a role of IgM in inducing transplant tolerance, thus decreasing the use of immunosuppressive agents; and 3) evaluating strategies (e.g. vaccines) to increase levels of such antibodies especially in patients awaiting transplantation. Other clinical studies are aimed at determining if there is an association between levels of such antibodies and severity of renal failure (e.g. after cardiac surgery) and severity of glomerular inflammation (e.g. in SLE or IgA nephropathy).
My clinical research involves transplant immunobiology, primarily focusing on B cell regulation, alloantibodies, and desensitizing patients with donor specific antibodies.
Lobo P, Schlegel KH, Spencer CE, Okusa MD, Chisolm C, Mchedlishvili N, Park A, Christ C, Burtner C. Naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) inhibit T cell activation and chemotaxis. J Immunol. 2008;180:1780-1791.
Li L, Huang L, Sung SS, Lobo PI, Brown MG, Gregg RK, Engelhard VH, Okusa MD. NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J Immunol. 2007;178:5899-5911.
Sevigny CP, Li L, Awad AS, Huang L, McDuffie M, Linden J, Lobo, PI, Okusa MD. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol 2007;178:4240-4249.
Hu DC, Burtner C, Hong A, Lobo PI, Okusa MD. Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. J Med Sciences. 2006;331:105-109.