Cirle A. Warren, MD
Graduate School: Univ East Ramon Magsaysay, Memorial Medical Center
Primary Appointment: Assistant Professor, Medicine, Infectious Diseases and International Health
Recognition, pathogenesis, impact, and control of enteric infections and the pathogenesis, diagnosis and management of inflammatory genital infections.
Email Address: email@example.com
Dr. Alcantara Warren's research is focused on the recognition, pathogenesis, impact, and control of enteric infections. She is also interested in the pathogenesis, diagnosis and management of inflammatory genital infections.
Dr. Warren is an assistant professor of medicine in the Division of Infectious Diseases and International Health at UVa. She is the medical director of the STD Clinic at the Charlottesville/Albermarle Health Department and on staff at the new Complicated C. difficile Clinic, providing Fecal Microbiota Transplant (FMT) services. She is also actively involved in mentoring international research fellows at UVa's Center for Global Health.
Dr. Warren graduated from the University of the Philippines and the University of the East Ramon Magsaysay Memorial Medical Center. She was trained in internal medicine at the Hospital of Saint Raphael in New Haven, Connecticut. She received training in infectious diseases at Uva-affiliated hospitals, including Roanoke Memorial Hospital and the Veterans Affairs Medical Center. Her training in geographic medicine and international health was completed at UVa's School Of Medicine.
Li Y, Figler RA, Kolling G, Bracken TC, Rieger J, Stevenson RW, Linden J, Guerrant RL, Warren CA. Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment. BMC Infect Dis. 2012 Dec 10;12:342. doi: 10.1186/1471-2334-12-342.
Warren CA, Li Y, Calabrese GM, Freire RS, Zaja-Milatovic S, van Opstal E, Figler RA, Linden J, Guerrant RL. Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection. Infect Immun. 2012 Dec;80(12):4463-73. doi: 10.1128/IAI.00782-12. Epub 2012 Oct 8.
Warren CA, Opstal EJ, Riggins MS, Li Y, Moore JH, Kolling GL, Guerrant RL, Hoffman PS. Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth and Recurrence of Clostridium difficile Infection in Mice. Antimicrob Agents Chemother. 2012 Nov 12. [Epub ahead of print]
Kolling GL, Wu M, Warren CA, Durmaz E, Klaenhammer TR, Guerrant RL. Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production. Gut Microbes. 2012 Nov-Dec;3(6):523-9. doi: 10.4161/gmic.21757. Epub 2012 Aug 16.
Warren CA, van Opstal E, Ballard TE, Kennedy A, Wang X, Riggins M, Olekhnovich I, Warthan M, Kolling GL, Guerrant RL, Macdonald TL, Hoffman PS. Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrob Agents Chemother. 2012 Aug;56(8):4103-11. doi: 10.1128/AAC.00360-12. Epub 2012 May 14.
Azevedo OG, Oliveira RA, Oliveira BC, Zaja-Milatovic S, Araújo CV, Wong DV, Costa TB, Lucena HB, Lima RC Jr, Ribeiro RA, Warren CA, Lima AÂ, Vitek MP, Guerrant RL, Oriá RB. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35. doi: 10.1186/1471-230X-12-35.
Warren CA, Labio E, Destura R, Sevilleja JE, Jamias JD, Daez ML. Clostridium difficile and Entamoeba histolytica infections in patients with colitis in the Philippines. Trans R Soc Trop Med Hyg. 2012 Jul;106(7):424-8. doi: 10.1016/j.trstmh.2012.04.005. Epub 2012 May 30.
Castro IC, Oliveira BB, Slowikowski JJ, Coutinho BP, Siqueira FJ, Costa LB, Sevilleja JE, Almeida CA, Lima AA, Warren CA, Oriá RB, Guerrant RL. Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase. Nutrition. 2012 Jun;28(6):678-85. doi: 10.1016/j.nut.2011.09.011. Epub 2012 Jan 20.
Costa LB, Noronha FJ, Roche JK, Sevilleja JE, Warren CA, Oriá R, Lima A, Guerrant RL. Novel in vitro and in vivo models and potential new therapeutics to break the vicious cycle of Cryptosporidium infection and malnutrition. J Infect Dis. 2012 May 1;205(9):1464-71. doi: 10.1093/infdis/jis216. Epub 2012 Mar 26.
Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL. Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice. BMC Infect Dis. 2012 Jan 20;12:13. doi: 10.1186/1471-2334-12-13.
D'Auria KM, Donato GM, Gray MC, Kolling GL, Warren CA, Cave LM, Solga MD, Lannigan JA, Papin JA, Hewlett EL. Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control. BMC Syst Biol. 2012 Jan 6;6:2. doi: 10.1186/1752-0509-6-2.
Viladomiu M, Hontecillas R, Pedragosa M, Carbo A, Hoops S, Michalak P, Michalak K, Guerrant RL, Roche JK, Warren CA, Bassaganya-Riera J. Modeling the role of peroxisome proliferator-activated receptor γ and microRNA-146 in mucosal immune responses to Clostridium difficile. PLoS One. 2012;7(10):e47525. doi: 10.1371/journal.pone.0047525. Epub 2012 Oct 11.PubMed Listings for this Faculty Member