Girija Ramakrishnan, PhD
Graduate School: State University of New York at Stony Brook
Primary Appointment: Assistant Professor, Medicine, Infectious Diseases and International Health
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Email Address: email@example.com
My major research focus is on mechanisms governing survival and
pathogenicity of the bacterium Francisella tularensis, that
causative agent of the disease tularemia. This highly infectious
organism may be transmitted by multiple routes including by aerosol and
an effective vaccine for the agent does not currently exist.
Iron, a key nutrient, is not readily available to the pathogen within
the host environment and our work is geared towards understanding the
mechanisms for iron acquisition of iron using a combination of genetic,
proteomic and bioinformatic approaches. We are also interested in
bacterial responses to iron and other environmental signals. Our
studies define novel nutrient acquisition mechanisms and may identify
suitable targets for development of vaccine and therapeutic
Girija Ramakrishnan is an affiliated faculty member of the Microbiology, Immunology and Infectious Diseases program.
Ramakrishnan G, Sen B and Johnson R. Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis. J. Biol. Chem. 287: 25191-25202, 2012 (PMID:22661710)
Sen B, Meeker A and Ramakrishnan G. The fslE homolog FTL_0439 (fupA/B) mediates siderophore-dependent iron uptake in Francisella tularensis LVS. Inf. Immun. 78(10):4276-4285, 2010 (PMC2950358).
Ramakrishnan G, Meeker A, and Dragulev B. fslE is necessary for siderophore-mediated iron acquisition in Francisella tularensis. J. Bacteriol. 190(15):5353-5361, 2008 (PMCID: PMC2493265).
Sullivan, JT, Jeffery EF, Shannon JD and Ramakrishnan G. Characterization of the siderophore of Francisella tularensis and role of fslA in siderophore production. J Bacteriol 188 (11):3785 -3795, 2006.
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