Richard D. Pearson, MD
Graduate School: University of Michigan
Primary Appointment: Professor, Medicine, Infectious Diseases and International Health
Email Address: email@example.com
Dr. Pearson, in collaboration with Selma M.B. Jeronimo, M.D., Ph.D., Universidade Federal do Rio Grande do Norte, Natal, Brazil, and Mary E. Wilson, M.D., University of Iowa School of Medicine, and their colleagues, has studied the immunogenetics, epidemiology and natural history of Leishmania infantum chagasi infection and visceral leishmaniasis in residents of northeastern Brazil. The majority of persons infected with L. i. chagasi develop protective, cell mediated Th1 responses to leishmanial antigens that result in asymptomatic, self-resolving infection. A subset of infected persons fail to develop protective Th1 responses and progress to visceral leishmaniasis. The collaborators are currently addressing the genetic correlates of infection using a family cohort. Dr. Pearson has also participated in the development of novel approaches to antileishmanial chemotherapy, and he has collaborated with Dr. Anastasio Q. Sousa at the Universidade Federal do Ceara, Fortaleza, Brazil, on the treatment of L. brazilinesis infections with fluconazole. Finally, he has worked with Janine Jagger, Ph.D., and colleagues on the prevention of sharp object and needle stick injuries among medical workers.
Chavali AK, Blazier AS, Tlaxca JL, Jensen PA, Pearson RD, Papin JA. Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease. BMC Syst Biol. 2012 Apr 27;6:27. doi: 10.1186/1752-0509-6-27.
Chavali AK, D'Auria KM, Hewlett EL, Pearson RD, Papin JA. A metabolic network approach for the identification and prioritization of antimicrobial drug targets. Trends Microbiol. 2012 Mar;20(3):113-23. doi: 10.1016/j.tim.2011.12.004. Epub 2012 Jan 31. Review.
Houpt ER, Pearson RD, Hall TL. Three domains of competency in global health education: recommendations for all medical students. Acad Med. 2007 Mar;82(3):222-5.
Perry JL, Pearson RD, Jagger J. Infected health care workers and patient safety: a double standard. Am J Infect Control. 2006 Jun;34(5):313-9. Review.
Reitsma AM, Closen ML, Cunningham M, Lombardo PA, Minich HN, Moreno JD, Nichols RL, Pearson RD, Sawyer RG, Wispelwey B, Tereskerz PM. Infected physicians and invasive procedures: safe practice management. Clin Infect Dis. 2005 Jun 1;40(11):1665-72. Epub 2005 May 2. Erratum in: Clin Infect Dis. 2005 Jul 1;41(1):136.
Pearson RD. Nitazoxanide As Treatment of Intestinal Parasites in Children. Curr Infect Dis Rep. 2004 Feb;6(1):25-26.