Amy J. Mathers, MD

Amy J. Mathers, MD

Amy  J.  Mathers
Degree(s): MD
Primary Appointment: Assistant Professor, Medicine, Infectious Diseases and International Health
Research Interests:
Molecular epidemiology of multidrug resistant gram negative bacilli, laboratory detection of gram negative antibiotic resistance, prevention of acquisition of resistant bacterial pathogens and treatment of multi-drug resistant gram negative bacteria.
Email Address:

Research Description

Evaluation of molecular epidemiology tools and in vitro detection of resistance through translational research at UVA based on a multi-species outbreak of Klebsiella pneumoniae carbapenemase (KPC) producing organisms.  Through the antimicrobial stewardship program perform evaluation of antibiotic usage and impact on the development of multidrug resistance gram negative bacilli infection.

My main clinical research evaluates the difference in patient outcomes stratified by carbapenem resistance mechanism.

Selected Publications

MacQueen DD, Lubelczyk C, Elias SP, Cahill BK, Mathers AJ, Lacombe EH, Rand PW, Smith RP Jr.  Genotypic diversity of an emergent population of Borrelia burgdorferi at a coastal Maine island recently colonized by Ixodes scapularis. Vector Borne Zoonotic Dis. 2012 Jun;12(6):456-61. doi: 10.1089/vbz.2011.0811. Epub 2012 Jan 4.

Smith RP Jr, Muzaffar SB, Lavers J, Lacombe EH, Cahill BK, Lubelczyk CB, Kinsler A, Mathers AJ, Rand PW.  Borrelia garinii in seabird ticks (Ixodes uriae), Atlantic Coast, North America. Emerg Infect Dis. 2006 Dec;12(12):1909-12.

Mathers AJ, Cox HL, Kitchel B, Bonatti H, Brassinga AK, Carroll J, Scheld WM, Hazen KC, Sifri CD.  Molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals Intergenus KPC carbapenemase transmission through a promiscuous plasmid. MBio. 2011 Nov 1;2(6):e00204-11. doi: 10.1128/mBio.00204-11. Print 2011.

Mathers AJ, Cox HL, Bonatti H, Kitchel B, Brassinga AK, Wispelwey B, Sawyer RG, Pruett TL, Hazen KC, Patel JB, Sifri CD.  Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients. Transpl Infect Dis. 2009 Jun;11(3):257-65. doi: 10.1111/j.1399-3062.2009.00374.x. Epub 2009 Feb 18.

Mathers AJ, Hazen KC, Carroll J, Yeh AJ, Cox HL, Bonomo RA, Sifri CD.  First Clinical Cases of OXA-48 Producing Carbapenem Resistant Klebsiella pneumoniae in the United States: the "menace" arrives in the New World. J Clin Microbiol. 2012 Nov 21. [Epub ahead of print]

PubMed Listings for this Faculty Member

Contact Information
Office Address: PO Box 801340,
Office Phone: +1 434-243-6454