Barbara J. Mann, PhD
Graduate School: University of Virginia
Primary Appointment: Associate Professor, Medicine, Infectious Diseases and International Health
Pathogenicity of Francisella tularensis and vaccines
Email Address: email@example.com
My research interests focus on the initial interactions between the pathogenic bacteria Francisella tularensis and its host. I am specifically interested in adherence and invasion mechanisms, and protective vaccines. F. tularensis has been designated as a category A select agent for studies in Biodefense Research.
Francisella tularensis is a zoonotic infection that can be contracted by several methods including tick bites and inhalation. The low infection dose of 10-50 organisms by an inhalation route led to its development as an agent of biological warfare. The molecular mechanisms of pathogenicity of this gram negative, intracellular bacteria are largely unknown. We are using combined approaches that include bioinformatics, and mutagenesis to identify proteins that mediate adherence to and invasion of host cells. We are also screening for attenuated strains that may be useful as protective vaccines.
Qin A, Scott DW, Rabideau MM, Moore EA, Mann BJ. Requirement of the CXXC motif of novel Francisella infectivity potentiator protein B FipB, and FipA in virulence of F. tularensis subsp. tularensis. PLoS One. 2011;6(9):e24611. Epub 2011 Sep 8.
Ark NM, Mann BJ.Impact of Francisella tularensis pilin homologs on pilus formation and virulence.Microb Pathog. 2011 Sep;51(3):110-20. Epub 2011 May 13.
Gilchrist CA, Moore ES, Zhang Y, Bousquet CB, Lannigan JA, Mann BJ, Petri WA. Regulation of Virulence of Entamoeba histolytica by the URE3-BP Transcription Factor. MBio. 2010 May 18;1(1). doi:pii: e00057-10. 10.1128/mBio.00057-10.
Mann BJ, Ark NM. Rationally designed tularemia vaccines. Expert Rev Vaccines. 2009 Jul;8(7):877-85. doi: 10.1586/erv.09.51. Review.
Qin A, Scott DW, Thompson JA, Mann BJ.Identification of an essential Francisella tularensis subsp. tularensis virulence factor. Infect Immun. 2009 Jan;77(1):152-61.
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