Eric R. Houpt, MD

Eric R. Houpt, MD

E. Houpt
Eric  R.  Houpt
Degree(s): MD
Graduate School: Emory University
Primary Appointment: Jack Gwaltney Professor of Medicine, Infectious Diseases and International Health
Research Interests:
Molecular diagnostics and Immunology
Email Address:

Research Description

Our laboratory is involved in several projects focused on molecular diagnostic tools for infectious diseases. Most work involves developing panels of PCR-based diagnostic tests to detect a full range of enteropathogens, and we utilize these tests in collaborative studies such as the MAL-ED and GEMS studies throughout Africa, Asia, and South America to better document the cause of diarrhea and malnutrition.  We also have a program on tuberculosis, both on developing rapid diagnostics that can identify which drugs to use for multidrug resistant Tb, as well as identifying markers for poor therapeutic response.

Selected Publications

1: Pholwat S, Liu J, Stroup S, Gratz J, Banu S, Rahman SM, Ferdous SS, Foongladda S, Boonlert D, Ogarkov O, Zhdanova S, Kibiki G, Heysell S, Houpt E. Integrated microfluidic card with TaqMan probes and high-resolution melt analysis to detect tuberculosis drug resistance mutations across 10 genes. MBio. 2015 Feb 24;6(2):e02273. doi: 10.1128/mBio.02273-14. PubMed PMID: 25714709; PubMed Central PMCID: PMC4357996.

2: Liu J, Kabir F, Manneh J, Lertsethtakarn P, Begum S, Gratz J, Becker SM, Operario DJ, Taniuchi M, Janaki L, Platts-Mills JA, Haverstick DM, Kabir M, Sobuz SU, Nakjarung K, Sakpaisal P, Silapong S, Bodhidatta L, Qureshi S, Kalam A, Saidi Q, Swai N, Mujaga B, Maro A, Kwambana B, Dione M, Antonio M, Kibiki G, Mason CJ, Haque R, Iqbal N, Zaidi AK, Houpt ER. Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study. Lancet Infect Dis. 2014 Aug;14(8):716-24. doi:10.1016/S1473-3099(14)70808-4. Epub 2014 Jul 9. PubMed PMID: 25022434.

3: Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infect Dis. 2015 Jan;15(1):85-94. doi: 10.1016/S1473-3099(14)70772-8. Epub 2014 Sep 29. Review. PubMed PMID: 25278220; PubMed Central PMCID: PMC4401121.

4: Platts-Mills JA, McCormick BJ, Kosek M, Pan WK, Checkley W, Houpt ER; MAL-ED Network Investigators. Methods of analysis of enteropathogen infection in the MAL-ED Cohort Study. Clin Infect Dis. 2014 Nov 1;59 Suppl 4:S233-8. doi:10.1093/cid/ciu408. PubMed PMID: 25305292; PubMed Central PMCID: PMC4204610.

5: Banu S, Rahman SM, Khan MS, Ferdous SS, Ahmed S, Gratz J, Stroup S, Pholwat S, Heysell SK, Houpt ER. Discordance across several methods for drug susceptibility testing of drug-resistant Mycobacterium tuberculosis isolates in a single laboratory. J Clin Microbiol. 2014 Jan;52(1):156-63. doi: 10.1128/JCM.02378-13. Epub 2013 Oct 30. PubMed PMID: 24172155; PubMed Central PMCID: PMC3911413.

6: Heysell SK, Moore JL, Keller SJ, Houpt ER. Therapeutic drug monitoring for slow response to tuberculosis treatment in a state control program, Virginia, USA. Emerg Infect Dis. 2010 Oct;16(10):1546-53. doi: 10.3201/eid1610.100374. PubMed PMID: 20875279; PubMed Central PMCID: PMC3294393.

7: Heysell SK, Houpt ER. The future of molecular diagnostics for drug-resistant tuberculosis. Expert Rev Mol Diagn. 2012 May;12(4):395-405. doi:10.1586/erm.12.25. Review. PubMed PMID: 22616704.

PubMed Listings for this Faculty Member

Contact Information
Office Address: PO Box 800136 MR-6, Room 1716A
Office Phone: 434-243-9326
Fax Phone: 434-924-0075