The Infectious Diseases Clinic cares for 350-400 HIV-infected patients in the Primary Care Center, which is a five minute walk from the Infectious Diseases Program labs in MR4 and Jordan Hall. It also provides support to satellite clinics that care for an additional 150 patients. Directors of the Clinic are Program graduates Brian Wispelwey, M.D. and Greg Townsend, M.D.

Clinical research conducted at the Clinic includes participation in antiretroviral protocols, protocols of the NIH Mycoses Study Group, and evaluation of therapies for opportunistic infections. More basic retroviral research, utilizing HIV isolates from patients, is conducted by  the Thaler Center.

The Clinic encompasses the AIDS Resource and Consultation Center, which serves half of the Commonwealth of Virginia by providing workshops, lectures, HIV testing and counseling courses, and a preceptor program. Trainees of the Infectious Disease Program receive instruction and participate in the care of HIV infected individuals through the clinic.