Ayotunde Dokun, MD, PhD

Ayotunde Dokun, MD, PhD

null Ayotunde Dokun
Degree(s): MD, PhD
Graduate School: Mt. Sinai School of Medicine (MD); Duke (Endocrinology fellowship)
Primary Appointment: Assistant Professor, Medicine, Endocrinology and Metabolism

Research Interests:
diabetes, genetics and PAD
Email Address: doa3q@virginia.edu

Research Description

Peripheral arterial disease (PAD) of the lower extremities is the result of arteriosclerotic blockage of blood vessels and its severity varies even among people with similar occlusions, suggesting a possible role for genetics in its severity. Individuals with diabetes are more likely to develop PAD and when people have PAD and diabetes, the disease is more severe resulting in higher risk of amputation and death. Therefore studies in our laboratory currently seek to understand how diabetes interacts with genetics and contribute to the poor outcomes in individuals with PAD.

We recently identified a genetic locus in mice which when present is associated with good outcomes in experimental PAD but its absence is associated with poor outcomes. Furthermore, we have now identified specific genes within this locus that modulate outcome in experimental PAD and at least of these genes is associated with severity of PAD in humans. We now have studies underway to understand the mechanism by which these genes impact outcomes in PAD. Additionally, we have ongoing studies to understand if the metabolic environment in diabetes interacts with these genes such that it contributes to poor outcomes in PAD. Findings from our studies are likely to provide novel insights into why diabetes has such a malignant influence on PAD severity.

Selected Publications

Dokun AO, Chen L, Lanjewar SS, Lye RJ, Annex BH. Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD. Cardiovasc Res. 2014 Mar 1;101(3):364-72. doi: 10.1093/cvr/cvt342. Epub 2014 Jan 2. PMID: 24385342

Hazarika S1, Farber CR, Dokun AO, Pitsillides AN, Wang T, Lye RJ, Annex BH. MicroRNA-93 controls perfusion recovery after hindlimb ischemia by modulating expression of multiple genes in the cell cycle pathway. Circulation. 2013 Apr 30;127(17):1818-28. doi: 10.1161/CIRCULATIONAHA.112.000860. Epub 2013 Apr 4.

Imoukhuede PI, Dokun AO, Annex BH, Popel AS. Endothelial cell-by-cell profiling reveals temporal dynamics of VEGFR1 and VEGFR2 membrane-localization following murine hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2013 Feb 1. [Epub ahead of print] PubMed PMID: 23376830.

Ellati RT, Dokun AO, Kavoussi PK, Steers WD, Annex BH, Lysiak JJ. Increased phosphodiesterase type 5 levels in a mouse model of type 2 diabetes mellitus. J Sex Med. 2013 Feb;10(2):362-9. doi: 10.1111/j.1743-6109.2012.02854.x. Epub 2012 Jul 19. PubMed PMID: 22812665.

Jones WS, Duscha BD, Robbins JL, Duggan NN, Regensteiner JG, Kraus WE, Hiatt WR, Dokun AO, Annex BH. Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. Vasc Med. 2012 Apr;17(2):94-100. doi: 10.1177/1358863X11436334. Epub 2012 Mar 8. PubMed PMID: 22402934.

Dokun AO, Annex BH. The VEGF165b "ICE-o-form" puts a chill on the VEGF story. Circ Res. 2011 Jul 22;109(3):246-7. doi: 10.1161/CIRCRESAHA.111.249953. PubMed PMID: 21778432; PubMed Central PMCID: PMC3196354.

Katwal AB, Dokun AO. Peripheral arterial disease in diabetes: is there a role for genetics? Curr Diab Rep. 2011 Jun;11(3):218-25. doi: 10.1007/s11892-011-0188-9. Review. PubMed PMID: 21424681; PubMed Central PMCID: PMC3137910.

Dokun AO. Lessons learned from glycemia control studies. Curr Diab Rep. 2010 Apr;10(2):133-8. doi: 10.1007/s11892-010-0094-6. Review. PubMed PMID: 20425572.

Dokun AO, Keum S, Hazarika S, Li Y, Lamonte GM, Wheeler F, Marchuk DA, Annex BH. A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation. 2008 Mar 4;117(9):1207-15. doi: 10.1161/CIRCULATIONAHA.107.736447. Epub 2008 Feb 19. PubMed PMID: 18285563; PubMed Central PMCID: PMC2881228.

Hazarika S, Dokun AO, Li Y, Popel AS, Kontos CD, Annex BH. Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. Circ Res. 2007 Oct 26;101(9):948-56. Epub 2007 Sep 6. PubMed PMID: 17823371.

Dokun AO, Chu DT, Yang L, Bendelac AS, Yokoyama WM. Analysis of in situ NK cell responses during viral infection. J Immunol. 2001 Nov 1;167(9):5286-93. PubMed PMID: 11673544.

Dokun AO, Kim S, Smith HR, Kang HS, Chu DT, Yokoyama WM. Specific and nonspecific NK cell activation during virus infection. Nat Immunol. 2001 Oct;2(10):951-6. PubMed PMID: 11550009.

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Contact Information

Office Address: PO Box 801406, Charlottesville, VA 22908-1406

Office Phone: 434-982-6544