Helmy M. Siragy, MD

Helmy M. Siragy, MD

null Helmy  M.  Siragy
Degree(s): MD
Graduate School: Tanta Univ, Egypt
Primary Appointment: Professor, Medicine, Endocrinology and Metabolism
Research Interests:
Biology and Pathophysiology of Angiotensin Receptor Subtypes in the Kidney and Heart Diseases

Email Address: hms7a@virginia.edu

Research Description

Dr. Helmy M. Siragy developed the microdialysis technique, which led to a golden age of revolutionary discoveries about the nature of angiotensin receptors and renal paracrine hormones. The lab focuses on the biology and pathophysiology of angiotensin subtype receptors in cardiovascular system. Currently the lab is conducting pioneering translational research that has major clinical impact and is related to cardiac ischemia, diabetic kidney disease, local tissue production of aldosterone and its paracrine functions in kidney and heart.

Dr. Siragy's lab is also involved in clinical studies related to aldosterone pulse activity in normal individuals and in patients with primary aldosteronism, vasopressin receptors in kidney and management of hyponatremia, and one of our ongoing studies investigating the effects of long term angiotensin subtype 1 receptor blockade on cardiovascular morbidity and mortality.

Selected Publications

Waeber B, Siragy HM. Mild hypertension: to treat or not to treat? Curr Hypertens Rep. 2013 Feb;15(1):1-2. doi: 10.1007/s11906-012-0317-0. PubMed PMID: 23152161.

Matavelli LC, Siragy HM. Reduction of aldosterone production improves renal oxidative stress and fibrosis in diabetic rats. J Cardiovasc Pharmacol. 2013 Jan;61(1):17-22. doi: 10.1097/FJC.0b013e318274d2ef. PubMed PMID: 23011470; PubMed Central PMCID: PMC3538933.

Matavelli LC, Huang J, Siragy HM. In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet. Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1652-7. doi: 10.1152/ajprenal.00204.2012. Epub 2012 Oct 17. PubMed PMID: 23077099; PubMed Central PMCID: PMC3532474.

Matavelli LC, Huang J, Siragy HM. Combined aliskiren and amlodipine reduce albuminuria via reduction in renal inflammation in diabetic rats. J Cardiovasc Pharmacol. 2012 Mar;59(3):281-7. doi: 10.1097/FJC.0b013e31823fc3f5. PubMed PMID: 22075749; PubMed Central PMCID: PMC3296909.

Huang J, Siragy HM. Sodium depletion enhances renal expression of (pro)rennin receptor via cyclic GMP-protein kinase G signaling pathway. Hypertension. 2012 Feb;59(2):317-23. doi: 10.1161/HYPERTENSIONAHA.111.186056. Epub 2011 Dec 27. PubMed PMID: 22203739; PubMed Central PMCID: PMC3266459.

Siragy HM. To ACCELERATE hypertension control. Curr Hypertens Rep. 2011 Aug;13(4):259-61. doi: 10.1007/s11906-011-0203-1. PubMed PMID: 21494776.

Abadir PM, Walston JD, Carey RM, Siragy HM. Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production. J Interferon Cytokine Res. 2011 Jun;31(6):471-4. doi: 10.1089/jir.2010.0043. Epub 2011 Feb 2. PubMed PMID: 21288138; PubMed Central PMCID: PMC3104285.

Huang J, Matavelli LC, Siragy HM. Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1-connective tissue growth factor signalling cascade. Clin Exp Pharmacol Physiol. 2011 Apr;38(4):215-21. doi: 10.1111/j.1440-1681.2011.05486.x. PubMed PMID: 21265872; PubMed Central PMCID: PMC3077929.

Siragy HM. Rationale for combining a direct renin inhibitor with other renin-angiotensin system blockers. Focus on aliskiren and combinations. Cardiovasc Drugs Ther. 2011 Feb;25(1):87-97. doi: 10.1007/s10557-010-6278-0. Review. PubMed PMID: 21213120.

Matavelli LC, Huang J, Siragy HM. Angiotensin AT₂ receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension. 2011 Feb;57(2):308-13. doi: 10.1161/HYPERTENSIONAHA.110.164202. Epub 2010 Dec 28. PubMed PMID: 21189405; PubMed Central PMCID: PMC3060557.

PubMed Listings for this Faculty Member

Contact Information
Office Address:
PO Box 801409
450 Ray C. Hunt Dr., Fontaine Research Park
Office Phone: 434-924-5629
Fax Phone: 434-982-3626
Website: http://www.medicine.virginia.edu/clinical/departments/medicine/divisions/endocrine/research/labs/siragy