Alda Vidrich, PhD

Alda Vidrich, PhD

Alda  Vidrich
Degree(s): PhD
Graduate School: University of Connecticut (PhD)
Primary Appointment: Associate Professor of Research, Medicine, Gastroenterology and Hepatology; Technical Director: Molecular Biology/Gene Expression Core
Research Interests: Etiology and pathogenesis of IBD, regulation of intestinal development and intestinal cell lineage allocation, regulation of intestinal stem cells and maintenance of the stem cell niche.
Email Address: av4x@virginia.edu


Research Description

Etiology and pathogenesis of IBD, regulation of intestinal development and intestinal cell lineage allocation, regulation of intestinal stem cells and maintenance of the stem cell niche.


Selected Publications

Brodrick B, Vidrich A, Porter E, Bradley L, Buzan JM, Cohn SM. Fibroblastgrowth factor receptor-3 (FGFR-3) regulates expression of paneth celllineage-specific genes in intestinal epithelial cells through bothTCF4/beta-catenin-dependent and -independent signaling pathways. J Biol Chem.2011 May 27;286(21):18515-25. doi: 10.1074/jbc.M111.229252. Epub 2011 Mar 9.

Buss SN, Hamano S, Vidrich A, Evans C, Zhang Y, Crasta OR, Sobral BW,Gilchrist CA, Petri WA Jr. Members of the Entamoeba histolytica transmembranekinase family play non-redundant roles in growth and phagocytosis. Int JParasitol. 2010 Jun;40(7):833-43. doi: 10.1016/j.ijpara.2009.12.007. Epub 2010Jan 18.

Shanahan, M.T., Vidrich, A., Shirafuji, Y., Dubois, C.L., Henschen-Edman, A., Hagen, Cohn, S.M., Ouellette, A.J. Elevated expression of paneth cell CRS4c in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J. Biol. Chem. (2010). 285(10):7493-504.

Fu Z, Kim J, Vidrich A, Sturgill TW, Cohn SM. Intestinal cell kinase, a MAPkinase-related kinase, regulates proliferation and G1 cell cycle progression ofintestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2009Oct;297(4):G632-40. doi: 10.1152/ajpgi.00066.2009. Epub 2009 Aug 20.

Vidrich A, Buzan JM, Brodrick B, Ilo C, Bradley L, Fendig KS, Sturgill T, CohnSM. Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development. Am JPhysiol Gastrointest Liver Physiol. 2009 Jul;297(1):G168-78. doi:10.1152/ajpgi.90589.2008. Epub 2009 Apr 30.

Barnes SL, Vidrich A, Wang ML, Wu GD, Cominelli F, Rivera-Nieves J, Bamias G, Cohn SM. Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. JImmunol. 2007 Nov 15;179(10):7012-20.

Vidrich A, Buzan JM, Barnes S, Reuter BK, Skaar K, Ilo C, Cominelli F, PizarroT, Cohn SM. Altered epithelial cell lineage allocation and global expansion ofthe crypt epithelial stem cell population are associated with ileitis inSAMP1/YitFc mice. Am J Pathol. 2005 Apr;166(4):1055-67.

Vidrich A, Buzan JM, Ilo C, Bradley L, Skaar K, Cohn SM. Fibroblast growthfactor receptor-3 is expressed in undifferentiated intestinal epithelial cellsduring murine crypt morphogenesis. Dev Dyn. 2004 May;230(1):114-23.

Vidrich A, Buzan JM, Cohn SM. Intestinal stem cells and mucosal gutdevelopment. Curr Opin Gastroenterol. 2003 Nov;19(6):583-90.

Rivera-Nieves J, Bamias G, Vidrich A, Marini M, Pizarro TT, McDuffie MJ,Moskaluk CA, Cohn SM, Cominelli F. Emergence of perianal fistulizing disease inthe SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology. 2003 Apr;124(4):972-82.

PubMed Listings for this Faculty Member

Contact Information
Office Address: PO Box 800708, MR-4, 1002, Charlottesville, VA  22908-0708
Phone: 434-243-6896
Fax: 434-924-7734