Steven M. Powell, MD
Graduate School: Indiana University (MD, residency); Johns Hopkins Oncology Center (fellowship)
Primary Appointment: Associate Professor, Medicine, Gastroenterology and Hepatology
Gastric cancer and Barrett's esophagus; colorectal cancer risk assessment and molecular tumorigenesis of gastric cancer
Email Address: email@example.com
Gastrointestinal cancers generate one of the largest health burdens on society. Therefore, advancing our current diagnostic, prognostic and therapeutic armamentaria to combat these lethal cancers is a primary focus of our team. Recent advances in the fields of molecular genetics and biology provide new avenues we are following to increase our understanding of the development of these gastrointestinal cancers. Investigations include molecular biologic analyses focused on both familial and sporadic cases of these cancers, including colorectal and gastric cancers.
In defining mechanisms of gastrointestinal tumorigenesis, we analyze tumor and normal specimens at the genetic and protein levels employing established and “state of the art” molecular techniques. We also are developing new methodologies to examine normal and tumor cells to identify critical changes in these cancers, and new avenues to best identify those at higher risk for colorectal cancer, and relaying recommendations appropriate to those at risk.
Uppal DS, Powell SM. Genetics/Genomics/Proteomics of gastric adenocarcinoma.Gastroenterol Clin North Am. 2013 Jun;42(2):241-60. doi:10.1016/j.gtc.2013.01.005. Epub 2013 Mar 5.
Sankpal NV, Moskaluk CA, Hampton GM, Powell SM. Overexpression of CEBPbetacorrelates with decreased TFF1 in gastric cancer. Oncogene. 2006 Jan26;25(4):643-9.
Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA,El-Rifai W. Expression of tight-junction protein claudin-7 is an early event ingastric tumorigenesis. Am J Pathol. 2005 Aug;167(2):577-84.
Sankpal NV, Mayo MW, Powell SM. Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta. Biochim Biophys Acta.2005 Apr 5;1728(1-2):1-10.
Fox CA, Sapinoso LM, Zhang H, Zhang W, McLeod HL, Petroni GR, Mullick T, Moskaluk CA, Frierson HF, Hampton GM, Powell SM. Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas. Neoplasia. 2005Apr;7(4):407-16.
Morris LE, Bloom GS, Frierson HF Jr, Powell SM. Nucleotide variants within theIQGAP1 gene in diffuse-type gastric cancers. Genes Chromosomes Cancer. 2005Mar;42(3):280-6.
Koon N, Zaika A, Moskaluk CA, Frierson HF, Knuutila S, Powell SM, El-Rifai W. Clustering of molecular alterations in gastroesophageal carcinomas. Neoplasia.2004 Mar-Apr;6(2):143-9.
Beckler AD, Roche JK, Harper JC, Petroni G, Frierson HF Jr, Moskaluk CA,El-Rifai W, Powell SM. Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas. Cancer. 2003 Nov 15;98(10):2184-91.
Beckler A, Moskaluk CA, Zaika A, Hampton GM, Powell SM, Frierson HF Jr,El-Rifai W. Overexpression of the 32-kilodalton dopamine and cyclic adenosine3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. Cancer.2003 Oct 1;98(7):1547-51.
Moskaluk CA, Zhang H, Powell SM, Cerilli LA, Hampton GM, Frierson HF Jr. Cdx2protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol. 2003 Sep;16(9):913-9.
|Office Address:||PO Box 800708, Charlottesville, VA 229908-0708