Patrick Northup, MD

Patrick Northup, MD

Patrick  Northup
Degree(s): MD
Graduate School: VCU Medical College of Virginia (MD); Univ of Virginia (residency, fellowship)
Primary Appointment: Associate Professor, Medicine, Gastroenterology and Hepatology
Research Interests: Viral hepatitis, liver transplantation, hepatocellular carcinoma, coagulation disorders in chronic liver disease, organ allocation, economic modeling, portal hypertension, hepatorenal syndrome, and medical education
Email Address: pgn5qs@Virginia.EDU

Research Description

Dr. Northup's research interests include viral hepatitis, liver transplantation, hepatocellular carcinoma, coagulation disorders in chronic liver disease, organ allocation, economic modeling, portal hypertension, hepatorenal syndrome, and medical education. With training in epidemiology, statistics, and economic outcome modeling, he is also interested in cost-effectiveness modeling and health policy.

Dr. Northup is active in both investigator initiated and industry-sponsored clinical trials and translational research evaluating new therapies for viral hepatitis, spontaneous bacterial peritonitis, coagulation disorders in cirrhosis, hepatorenal syndrome, liver transplantation organ allocation, upper GI bleeding, and hepatocellular carcinoma. He also has regulatory and policy interests and is a former member of the University of Virginia, Institutional Review Board for Human Research.  He is a consultant to the U.S. FDA and the U.S. National Institutes of Health and is the recipient of the 2007 American Association for the Study of Liver Diseases Jan Albrecht award for clinical research.

Selected Publications

Prophylactic anticoagulation for venous thromboembolism in hospitalized cirrhosis patients is not associated with high rates of gastrointestinal bleeding. Intagliata NM, Henry ZH, Shah N, Lisman T, Caldwell SH, Northup PG. Liver Int. 2014 Jan;34(1):26-32. doi: 10.1111/liv.12211. Epub 2013 Jun 12.

Coagulation in liver disease: a guide for the clinician. Northup PG, Caldwell SH. Clin Gastroenterol Hepatol. 2013 Sep;11(9):1064-74. doi: 10.1016/j.cgh.2013.02.026. Epub 2013 Mar 16.

Established and new-generation antithrombotic drugs in patients with cirrhosis - possibilities and caveats. Lisman T, Kamphuisen PW, Northup PG, Porte RJ. J Hepatol. 2013 Aug;59(2):358-66. doi: 10.1016/j.jhep.2013.03.027. Epub 2013 Mar 30.

Procedural competency of gastroenterology trainees: from apprenticeship to milestones. Northup PG, Argo CK, Muir AJ, Decross AJ, Coyle WJ, Oxentenko AS. Gastroenterology. 2013 Apr;144(4):677-80. doi: 10.1053/j.gastro.2013.02.020. Epub 2013 Feb 21. No abstract available.

Peripheral platelet count correlates with liver atrophy and predicts long-term mortality on the liver transplant waiting list. Bleibel W, Caldwell SH, Curry MP, Northup PG. Transpl Int. 2013 Apr;26(4):435-42. doi: 10.1111/tri.12064. Epub 2013 Jan 29.

Multimodality endoscopic treatment of pancreatic duct disruption with stenting and pseudocyst drainage: how efficacious is it? Shrode CW, Macdonough P, Gaidhane M, Northup PG, Sauer B, Ku J, Ellen K, Shami VM, Kahaleh M. Dig Liver Dis. 2013 Feb;45(2):129-33. doi: 10.1016/j.dld.2012.08.026. Epub 2012 Oct 1.

A clinical survey of bleeding, thrombosis, and blood product use in decompensated cirrhosis patients. Shah NL, Northup PG, Caldwell SH. Ann Hepatol. 2012 Sep-Oct;11(5):686-90.

Hepatocellular carcinoma and model for end-stage liver disease exceptions: the more we understand, the more challenging the allocation gets. Northup PG, Berg CL. Liver Transpl. 2012 Apr;18(4):381-3. doi: 10.1002/lt.23409. No abstract available.

Editorial: Beta-blockers and the prevention of decompensation in cirrhosis: worth the trouble. Northup PG, Henry ZH. Am J Gastroenterol. 2012 Mar;107(3):428-30. doi: 10.1038/ajg.2011.466.

Hypercoagulation and thrombophilia in nonalcoholic fatty liver disease: mechanisms, human evidence, therapeutic implications, and preventive implications. Northup PG, Argo CK, Shah N, Caldwell SH. Semin Liver Dis. 2012 Feb;32(1):39-48. doi: 10.1055/s-0032-1306425. Epub 2012 Mar 13. Review.

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Contact Information
Office Address: PO Box 800708, Charlottesville, VA 22908-0708
Office Phone: 434-243-2718
Fax Phone: 434-244-7529