Stephen H. Caldwell, MD

Stephen H. Caldwell, MD

Stephen  H.  Caldwell
Degree(s): MD
Graduate School: Bowman Gray School of Medicine of Wake Forest University
Primary Appointment: Professor, Medicine, Gastroenterology and Hepatology
Research Interests:
Steatohepatitis, cirrhosis, variceal bleeding, hepatocellular cancer, coagulopathy in liver disease, and viral hepatitis
Email Address: shc5c@virginia.edu

Research Description

Fatty liver disease, coagulopathy and hemostasis in liver disease, gastric variceal bleeding, viral hepatitis, hepatocellular cancer, alcoholic liver disease, ascites, techniques in liver biopsy.


Selected Publications

Cupino AC, Hair CD, Angle JF, Caldwell SH, Rich TA, Berg CL, Northup PG, Al-Osaimi AM, Argo CK. Does external beam radiation therapy improve survival following transarterial chemoembolization for unresectable hepatocellular carcinoma? Gastrointest Cancer Res. 2012 Jan;5(1):13-7.

Shah N, Northup P, Caldwell S. A Clinical Survey of Bleeding, Thrombosis, and Blood Product use in Decompensated Cirrhosis Patients. Ann Hepatol 2012 accepted

Caldwell SH. Gastric varices: Is there a role for endoscopic cyanoacrylates or are we entering the BRTO Era? Am J Gastro (Red Section) 2012 Accepted

Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace. J Hepatol. 2012 Feb 9. [Epub ahead of print]

Caldwell SH, Intagliata N. Invited Commentary for Hepatology Elsewhere in Hepatology. Coagulopathy of Liver Disease: An old dogma dies hard. Hepatology 2012

Northup PG, Argo CK, Shah N, Caldwell SH. Hypercoagulation and thrombophilia in nonalcoholic fatty liver disease: mechanisms, human evidence, therapeutic implications, and preventive implications.  Semin Liver Dis. 2012 Feb;32(1):39-48

Lisman T, Caldwell SH, Porte RJ. Anemia as a potential contributor to bleeding in patients with liver disease - Neglected but not forgotten. J Hepatol. 2011;54:594-5.

Sabri SS, Swee W, Turba UC, Saad WE, Park AW, Al-Osaimi AM, Caldwell SH, Matsumoto AH, Angle JF. Bleeding Gastric Varices Obliteration with Balloon-occluded Retrograde Transvenous Obliteration Using Sodium Tetradecyl Sulfate Foam. J Vasc Interv Radiol. 2011;22:309-16.

Truesdale AE, Caldwell SH, Shah NL, Argo CK, Al-Osaimi AM, Schmitt TM, Northup PG. Sorafenib therapy for hepatocellular carcinoma prior to liver transplant is associated with increased complications after transplant. Transpl Int. 2011 Oct;24(10):991-8

Lisman T, Caldwell SH, Burroughs AK, Northup PG, Senzolo M, Stravitz RT, Tripodi A, Trotter JF, Valla DC, Porte RJ; Coagulation in Liver Disease Study Group. Hemostasis and thrombosis in patients with liver disease: The ups and downs. J Hepatol. 2010;53:362-71

Ratziu V, Caldwell S, Neuschwander-Tetri BA. Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues. Hepatology. 2010;52:2206-15

Caldwell S, Ikura Y, Dias D, Isomoto K, Yabu A, Moskaluk C, Pramoonjago P, Simmons W, Scruggs H, Rosenbaum N, Wilkinson T, Toms P, Argo CK, Al-Osaimi AM, Redick JA. Hepatocellular ballooning in NASH. J Hepatol 2010;53:719-23

Cotrim HP, Freitas LA, Alves E, Almeida A, May DS, Caldwell S. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):969-72.

Caldwell SH, Freitas  LAR, Park SH, Moreno MLV, Redick JA, Davis CA, Sisson BJ, Patrie JT, Cotrim HP, Argo CK, Al-Osaimi AM. Intramitochondrial Crystalline Inclusions in Nonalcoholic Steatohepatitis. Hepatology. 2009;49:1888-95.

Caldwell S, Lee VD, Kleiner DE, Al-Osaimi AMS, Argo CK, Northup PG, Berg CL, Schmitt T. Cryptogenic Cirrhosis and NASH: A histological analysis. Ann Hepatology 2009;8:346-352.

Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol. 2009;51:371-9.

Fujii H, Ikura Y, Arimoto J, Sugioka K, Iezzoni JC, Park SH, Naruko T, Itabe H, Kawada N, Caldwell SH, Ueda M. Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. J Atheroscler Thromb. 2009;16:893-901

Tripodi A, Caldwell SH, Hoffman M, Trotter JF, Sanyal AJ. The Prothrombin Time Test as a Measure of Bleeding Risk and Prognosis in Liver Disease. Alimentary Pharmacology and Therapeutics 2007:26:141-8.


PubMed Listings for this Faculty Member


Contact Information
Office Address: PO Box 800708 Hospital West,
Office Phone: +1 434-924-2626
Fax Phone: +1 434-924-0491