Christopher M. Kramer, MD
Graduate School: University of CA, San Francisco
Primary Appointment: Ruth C. Heede Professor of Cardiology, Professor of Radiology; Director, Cardiovascular Imaging Center
Cardiac magnetic resonance imaging; left ventricular remodeling; atherosclerotic plaque imaging; peripheral arterial disease; myocardial Infarction; myocardial function; myocardial viability; coronary artery Imaging; atherosclerotic plaque imaging.
Email Address: firstname.lastname@example.org
Cardiovascular magnetic resonance imaging is a powerful technology that offers a comprehensive imaging approach to ischemic heart disease. A major focus of our work is on developing clinical applications of cardiovascular MRI. Active clinical protocols include developing a comprehensive MR exam for clinical trials in peripheral arterial disease including atherosclerotic plaque imaging and calf muscle perfusion and energetics at peak exercise.
Other clinical studies include quantitative myocardial perfusion imaging in microvascular coronary disease, predicting the development of LV dysfunction from chemotherapeutic agents, quantitative myocardial functional imaging as a measure of dyssynchrony in heart failure, coronary artery and wall imaging, and imaging of left atrial structure and mechanics.
Lipinski M, McVey C, Berger J, Kramer CM, Salerno M. Prognostic value of stress cardiac magnetic resonance imaging in patients with know or suspected coronary artery disease: A systematic review and meta-analysis. J Am Coll Cardiol, 2013; in press.
Jiji RS, Pollak AW, Epstein FH, Antkowiak PF, Meyer CH, Weltman AL, Lopez D, DiMaria JM, Hunter JR, Christopher JM, Kramer CM. Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease. J Cardiovasc Magn Reson. 2013 Jan 23;15:14. doi: 10.1186/1532-429X-15-14. PubMed PMID: 23343398; PubMed Central PMCID: PMC3562222.
Pollak AW, Meyer CH, Epstein FH, Jiji RS, Hunter JR, Dimaria JM, Christopher JM, Kramer CM. Arterial spin labeling MR imaging reproducibly measures peak-exercise calf muscle perfusion: a study in patients with peripheral arterial disease and healthy volunteers. JACC Cardiovasc Imaging. 2012 Dec;5(12):1224-30. doi: 10.1016/j.jcmg.2012.03.022. PubMed PMID: 23236972; PubMed Central PMCID: PMC3531823.
Pollak AW, Norton PT, Kramer CM. Multimodality imaging of lower extremity peripheral arterial disease: current role and future directions. Circ Cardiovasc Imaging. 2012 Nov;5(6):797-807. doi: 10.1161/CIRCIMAGING.111.970814. Review. PubMed PMID: 23169982; PubMed Central PMCID: PMC3504350.
Bourque JM, Schietinger BJ, Kennedy JL, Christopher JM, Taylor AM, McNamara CA, Kramer CM. Usefulness of cardiovascular magnetic resonance of of the superficial femoral artery for screening patients with diabetes mellitus for atherosclerosis. Am J Card, 2012;110:50-56.
Green JJ, Berger J, Kramer CM, Salerno M. Prognostic value of cardiac magnetic resonance late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy. J Am Coll Cardiol Img, 2012;5:370-377.
West AM, Anderson JD, Meyer CH, Epstein FH, Wang H, Hagspiel KD, Berr SS, Harthun NL, DiMaria JM, Hunter JR, Christopher JM, Chew JD, Winberry GB, Kramer CM. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon timing of statin initiation. Atherosclerosis, 2011;218:156-162
West AM, Anderson JD, Meyer CH, Epstein FH, Wang H, Hagspiel KD, Berr SS, Harthun NL, Weltman AL, DiMaria JM, Hunter JR, Christopher JM, Kramer CM. LDL lowering does not improve calf muscle perfusion, energetics, or exercise performance in peripheral arterial disease. J Am Coll Cardiol, 2011;58:1068-76
Parmar J, Rogers WJ, Mugler J, Baskurt E, Altes TA, Nandalur KR, Stukenborg G, Phillips CD, Hagspiel KD, Matsumoto AH, Dake MD, Kramer CM. MRI of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. Circulation, 2010;122:2031-2038
Patel A, Antkowiak PF, Nandalur KR, West AM, Salerno M, Arora V, Christopher J, Epstein FH, Kramer CM. Assessment of advanced coronary artery disease: advantages of quantitative magnetic resonance perfusion analysis. J Am Coll Cardiol, 2010;56:561-569