Alexander L. Klibanov, PhD

Alexander L. Klibanov, PhD

Alexander  L.  Klibanov
Degree(s): PhD
Graduate School: National Cardiology Research Center, Russia (PhD)
Primary Appointment: Associate Professor, Medicine, Cardiovascular Medicine
Research Interests:
Targeted delivery of therapeutic and diagnostic imaging agents.
Email Address: alk6n@virginia.edu

Research Description

Ultrasound imaging is a widespread and inexpensive non-invasive diagnostic technique. Ultrasound contrast agents offer a flexible platform that can be used for diagnostic imaging as a blood pool marker (tissue perfusion), as a targeted marker for imaging of inflammation, angiogenesis, and also as adjunct microdevices for enhanced targeted drug delivery and gene therapy.

In diagnostic imaging, detection of contrast material offers high sensitivity (individual micron-sized particles can be visualized in vitro and in vivo by ultrasound medical imaging systems). We prepare and analyze such ultrasound contrast materials, attach targeting ligands (antibodies, peptides) and plasmid DNA to their surface for targeting and ultrasound-enhanced delivery. Using colloid chemistry-based approaches, stable microbubbles with extended circulation lifetime are designed; polymer brush coating is applied to ensure enhanced stability.


Selected Publications

Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizzaro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release. 2013 Feb 10;165(3):216-25. doi: 10.1016/j.jconrel.2012.10.021. Epub 2012 Nov 8. PubMed PMID: 23142578.

Kilroy JP, Klibanov AL, Wamhoff BR, Hossack J. Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force. IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Oct;59(10):2156-66. doi:
10.1109/TUFFC.2012.2442. PubMed PMID: 23143566.

Burke CW, Suk JS, Kim AJ, Hsiang YH, Klibanov AL, Hanes J, Price RJ. Markedly  enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. J Control Release.
2012 Sep 10;162(2):414-21. doi: 10.1016/j.jconrel.2012.07.005. Epub 2012 Jul 16. PubMed PMID: 22800583; PubMed Central PMCID: PMC3438364.

Unnikrishnan S, Klibanov AL. Microbubbles as ultrasound contrast agents for molecular imaging: preparation and application. AJR Am J Roentgenol. 2012 Aug;199(2):292-9. doi: 10.2214/AJR.12.8826. Review. PubMed PMID: 22826389.

Naresh NK, Xu Y, Klibanov AL, Vandsburger MH, Meyer CH, Leor J, Kramer CM, French BA, Epstein FH. Monocyte and/or macrophage infiltration of heart after myocardial infarction: MR imaging by using T1-shortening liposomes. Radiology. 2012 Aug;264(2):428-35. doi: 10.1148/radiol.12111863. Epub 2012 Jun 21. PubMed PMID: 22723500; PubMed Central PMCID: PMC3401349.

Phillips LC, Dhanaliwala AH, Klibanov AL, Hossack JA, Wamhoff BR. Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2853-5. doi: 10.1161/ATVBAHA.111.238170. Epub 2011 Sep 29. PubMed PMID: 21960561.

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA. Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation. J Control Release. 2011 Aug 25;154(1):42-9. doi:
10.1016/j.jconrel.2011.04.020. Epub 2011 Apr 23. PubMed PMID: 21549778; PubMed Central PMCID: PMC3148278.

Patil AV, Rychak JJ, Klibanov AL, Hossack JA. Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results. Mol Imaging. 2011 Aug;10(4):238-47. doi:
10.2310/7290.2011.00002. Epub 2011 Apr 26. PubMed PMID: 21521555; PubMed Central PMCID: PMC3127411.

Lu Z, Elliott MR, Chen Y, Walsh JT, Klibanov AL, Ravichandran KS, Kipnis J. Phagocytic activity of neuronal progenitors regulates adult neurogenesis. Nat Cell Biol. 2011 Jul 31;13(9):1076-83. doi: 10.1038/ncb2299. PubMed PMID:
21804544; PubMed Central PMCID: PMC3374401.

Burke CW, Klibanov AL, Sheehan JP, Price RJ. Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating. J Neurosurg. 2011 Jun;114(6):1654-61. doi: 10.3171/2010.11.JNS101201. Epub 2011 Jan 7. PubMed PMID: 21214331.

PubMed Listings for this Faculty Member


Contact Information
Office Address: PO Box 801394 CVRC/Cardiovascular Division,
Office Phone: +1 434-243-9773