Lawrence W. Gimple, MD

Lawrence W. Gimple, MD


Lawrence  W.  Gimple
Degree(s): MD
Graduate School: Harvard Medical School (MD); Massachusetts General Hospital (IM residency); Massachusetts General Hospital (Cardiology and Interventional Cardiology Fellowship)
Primary Appointment: Professor, Medicine, Cardiovascular Medicine; Director, Clinical Cardiology; Co-Director, Heart and Vascular Center
Research Interests:
Interventional cardiology; mechanisms of restenosis following vascular interventions; new educational teaching tools using multimedia and digital techniques.
Email Address:

Research Description

Dr. Gimple is involved in clinical research trials related to acute myocardial infarction, lipid management in patients with acute coronary syndromes, trials of antithrombotic therapy for patients undergoing coronary stenting for acute coronary syndromes, and research in stroke prevention in patients with a patent foramen ovale. Patients with acute coronary syndromes are often treated in the cardiac catheterization laboratory and these trials address opportunities to optimize the use of stents and anti-thrombotic agents. Young patients with strokes often have a patient foramen ovale, and this research addresses whether these patients are optimally treated by closing the intra-cardiac communication or by treating with medications alone.

Selected Publications

Keeley EC, Moorman JR, Liu L, Gimple LW, Lipson LC, Ragosta M, Taylor AM, Lake DE, Burdick MD, Mehrad B, Strieter RM. Plasma chemokine levels are associated with the presence and extent of angiographic coronary collaterals in chronic ischemic heart disease. PLoS One. 2011;6(6):e21174. doi: 10.1371/journal.pone.0021174. Epub 2011 Jun 22. PubMed PMID: 21731663; PubMed Central PMCID: PMC3120847.

Enkiri SA, Taylor AM, Keeley EC, Lipson LC, Gimple LW, Ragosta M. Coronary angiography is a better predictor of mortality than noninvasive testing in patients evaluated for renal transplantation. Catheter Cardiovasc Interv. 2010 Nov 15;76(6):795-801. doi: 10.1002/ccd.22656. PubMed PMID: 20518007; PubMed Central PMCID: PMC2991378.

Jones DG, Taylor AM, Enkiri SA, Lobo P, Brayman KL, Keeley EC, Lipson LC, Gimple LW, Ragosta M. Extent and severity of coronary disease and mortality in patients with end-stage renal failure evaluated for renal transplantation. Am J Transplant. 2009 Aug;9(8):1846-52. doi: 10.1111/j.1600-6143.2009.02703.x. Epub 2009 Jun 16. PubMed PMID: 19538490; PubMed Central PMCID: PMC2850065.

Ragosta M, Bishop AH, Lipson LC, Watson DD, Gimple LW, Sarembock IJ, Powers ER. Comparison between angiography and fractional flow reserve versus single-photon emission computed tomographic myocardial perfusion imaging for determining lesion significance in patients with multivessel coronary disease. Am J Cardiol. 2007 Apr 1;99(7):896-902. Epub 2007 Feb 12. PubMed PMID: 17398179.

Chhatriwalla AK, Ragosta M, Powers ER, Sarembock IJ, Gimple LW, Fischer JJ, Barringhaus KG, Kramer CM, Samady H. High left ventricular mass index does not limit the utility of fractional flow reserve for the physiologic assessment of lesion severity. J Invasive Cardiol. 2006 Nov;18(11):544-9. PubMed PMID: 17090819.

Fischer JJ, Wang XQ, Samady H, Sarembock IJ, Powers ER, Gimple LW, Ragosta M. Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment. Catheter Cardiovasc Interv. 2006 Oct;68(4):544-8. PubMed PMID: 16969847.

Ragosta M, Dee S, Sarembock IJ, Lipson LC, Gimple LW, Powers ER. Prevalence of unfavorable angiographic characteristics for percutaneous intervention in patients with unprotected left main coronary artery disease. Catheter Cardiovasc Interv. 2006 Sep;68(3):357-62. PubMed PMID: 16892431.

Ragosta M, Samady H, Isaacs RB, Gimple LW, Sarembock IJ, Powers ER. Coronary flow reserve abnormalities in patients with diabetes mellitus who have end-stage renal disease and normal epicardial coronary arteries. Am Heart J. 2004 Jun;147(6):1017-23. PubMed PMID: 15199350.

McClish JC, Ragosta M, Powers ER, Barringhaus KG, Gimple LW, Fischer J, Garnett J, Siadaty M, Sarembock IJ, Samady H. Effect of acute myocardial infarction on the utility of fractional flow reserve for the physiologic assessment of the severity of coronary artery narrowing. Am J Cardiol. 2004 May 1;93(9):1102-6. PubMed PMID: 15110200.

Ragosta M, Samady H, Gimple LW, Sarembock IJ, Fenster M, Powers ER. Percutaneous treatment of focal vs. diffuse in-stent restenosis: a prospective randomized comparison of conventional therapies. Catheter Cardiovasc Interv. 2004 Mar;61(3):344-9. PubMed PMID: 14988893.

PubMed Listings for this Faculty Member

Contact Information

Office Address: PO Box 800158 Hospital Expansion Bldg; Room 4023,

Office Phone: +1 434-924-9591

Fax Phone: +1 434-982-1998