Judith A. Woodfolk, MD, PhD
Degree(s): MD, PhD
Graduate Schools: Univ of Sheffield, University of Virginia
Primary Appointment: Associate Professor, Medicine, Allergy and Clinical Immunology
Cellular mechanisms of allergic disease in humans.
Email Address: email@example.com
My research is driven by theories which challenge current concepts, and by novel ideas, related to the role of T cells, dendritic cells and basophils in allergic disease. The primary objective of my work is to gain new insight into cellular mechanisms that initiate and promote allergic responses in humans. My foray into cellular immunology began during my thesis work which focused on defining major T cell epitopes of allergens in humans.
Current projects include: (1) analysis of the role of effector and regulatory T cells in severe allergic disease; (2) cellular and molecular studies on the role of TSLP and its receptor in allergic disease; (3) investigation of the role of extracellular matrix molecules in atopic dermatitis; and (4) immune mechanisms of rhinovirus-induced asthma exacerbations. Our work involves a high degree of collaboration with clinical specialists in adult and pediatric allergy and pediatric respiratory medicine, as well as with basic scientists in the fields of murine immunology, virology, biochemistry, genetics, epigenetics, and molecular biology. By focusing on human-based systems, we aim to accelerate the transition of experimental findings from the bench to the bedside.
Wisniewski J.A., Agrawal R., Woodfolk J.A. (2013). Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin. Exp. Allergy 43:164-176. (Review).
Platts-Mills T.A., Woodfolk J.A. (2011). Allergens and their role in the allergic immune response. Immunol. Rev. 242:51-68. (Review).
Reefer A.J., Hulse K.E., Lannigan, J.A., Solga M.D., Wright P.W., Kelly L.A., Patrie J., Chapman M.D., Woodfolk J.A. (2010). Flow cytometry imaging identifies rare Th2 cells expressing thymic stromal lymphopoietin receptor in a “pro-allergic” milieu. J. Allergy Clin. Immunol. 126:1049-1058. [PMCID: PMC3034251].
Hulse K.E., Reefer A.J., Engelhard V.H., Patrie J.T., Ziegler S.F., Chapman M.D., Woodfolk J.A. (2010). Targeting allergen to FcRI reveals a novel Th2 regulatory pathway linked to TSLP receptor. J. Allergy Clin. Immunol. 125:247-256. [PMCID: PMC2688453].
Reefer A.J., Satinover S.M., Solga M.D., Lannigan J.A., Nguyen J.T., Wilson B.B., Woodfolk J.A. (2008). Analysis of CD25hiCD4+ “regulatory” T cell subtypes in atopic dermatitis reveals a novel Th2-like population. J. Allergy Clin. Immunol. 121:415-422.
Hulse K.E., Reefer A.J., Engelhard V.H., Satinover S.M., Patrie J.T., Chapman M.D., Woodfolk J.A. (2008). Targeting Fel d 1 to FcRI induces a novel variation of the Th2 response in subjects with cat allergy. J. Allergy Clin. Immunol. 121:756-762.
Satinover S.M., Reefer A.J., Pomes A., Chapman M.D., Platts-Mills T.A.E., and Woodfolk J.A. (2005). Specific IgE and IgG antibody binding patterns to recombinant cockroach allergens. J. Allergy Clin. Immunol. 115:803-809.
Reefer A.J., Carneiro R.M., Custis N.J., Platts-Mills T.A.E., Sung S.J., Hammer J., and Woodfolk J.A. (2004). A role for IL-10-mediated HLA-DR7-restricted T-cell dependent events in development of the modified Th2 response to cat allergen. J. Immunol. 172:2763-2772.
Woodfolk J.A., Sung S.J., Benjamin D.C., Lee J.K., Platts-Mills T.A.E. (2000). Distinct human T cell repertoires mediate immediate & delayed-type hypersensitivity responses to the Trichophyton antigen, Tri r 2. J. Immunol. 165:4379-87.