John W. Steinke, PhD

John W. Steinke, PhD

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John  W. Steinke
Degree(s): PhD
Graduate School: Texas A & M University, College Station
Primary Appointment: Associate Professor, Medicine, Allergy and Clinical Immunology

Research Interests:

Fibrotic responses in the development of nasal polyposis and the functional analysis of gene involved in asthma and sinus disease
Email Address: js3ch@virginia.edu

Research Description

Nasal polyposis is a disease characterized by the recurrent growth of tissue from the middle turbinant of the sinus tissue. The mechanism of polyp formation is unknown, so we are characterizing the cellular components that are involved in directing and maintaining polyp growth. We have found an overexpression of cysteinyl leukotrienes and the enzymes involved in their synthesis in polyp tissue sub-types compared to controls. Additional work is centered on determining the role that hypoxia plays in promoting the fibrosis observed in non-eosinophilic sinusitis.


Selected Publications

Steinke JW. Editorial: Yin-Yang of EP receptor expression. J Leukoc Biol. 2012 Dec;92(6):1129-31. doi: 10.1189/jlb.0812374.

Steinke JW, Payne SC, Chen PG, Negri J, Stelow EB, Borish L. Etiology of nasal polyps in cystic fibrosis: not a unimodal disease. Ann Otol Rhinol Laryngol. 2012 Sep;121(9):579-86.

Posthumus J, Tiñana A, Mozena JD, Steinke JW, Borish L. Autoimmune mechanisms in chronic idiopathic urticaria. J Allergy Clin Immunol. 2012 Sep;130(3):814-816.e4. doi: 10.1016/j.jaci.2012.04.037.

Medina JG, Steinke JW, Das S. A chitosan-based sinus sealant for reduction of adhesion formation in rabbit and sheep models. Otolaryngol Head Neck Surg. 2012 Aug;147(2):357-63. doi: 10.1177/0194599812443647.

Borish L, Steinke JW. The promise and obstacles of asthma genetics research. Ann Allergy Asthma Immunol. 2012 Jun;108(6):388-9. doi:10.1016/j.anai.2012.03.017.

Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, Murphy DD, Odio S, James HR, Patrie JT, Hunt W, O'Rourke AK, Davis MD, Steinke JW, Lu X, Kennedy J, Heymann PW. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012 Jun;129(6):1499-1505.e5. doi: 10.1016/j.jaci.2012.03.040.

Steinke JW, Kennedy JL. Leukotriene Inhibitors in Sinusitis. Curr Infect Dis Rep. 2012 Jan 29. [Epub ahead of print]

Steinke JW, Payne SC, Borish L. Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization. J Allergy (Cairo). 2012;2012:182090. doi:10.1155/2012/182090.

Payne SC, Borish L, Steinke JW. Genetics and phenotyping in chronic sinusitis. J Allergy Clin Immunol. 2011 Oct;128(4):710-20; quiz 721-2. doi: 10.1016/j.jaci.2011.05.022.

Payne SC, Early SB, Huyett P, Han JK, Borish L, Steinke JW. Evidence for distinct histologic profile of nasal polyps with and without eosinophilia. Laryngoscope. 2011 Oct;121(10):2262-7. doi: 10.1002/lary.21969.

 


Contact Information

Office Address: PO Box 801355
Charlottesville VA, 22908-1355

Office Phone: 434-982-3270

Fax Phone: 434-924-5779