Mark A. Kirk, MD

Mark A. Kirk, MD

Research Home, Publications

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Refereed Journals:

  • Vandegrift V, Kirk MA: Chemical preservation of protein in industrial whole animal blood. J Agric Food Chem. 1981 May-Jun;29(3):671-3.
  • Cohen A, Reyes R, Kirk M, Fulks R: Osler's nodes, pseudoaneurysm formation, and sepsis complicating percutaneous radical artery cannulation.  Critical Care Medicine 1984; 12:1078 – 1079.
  • Kulig K, Moore L, Kirk M, Stallworth J, Rumack B: Bromocriptin-associated headache: Possible life-threatening sympathomimetic interaction.  Obstet Gynecol  78: 941, 1991.
  • Kirk M, Gerrace R, Kulig K:  Cyanide and methemoglobin kinetics in smoke inhalation: Victims treated with the cyanide antidote kit.  Ann Emerg Med  1993; 22:1413-1418.
  • Burkhart K, Brent J, Kirk M, Baker D, Kulig K:  Comparison of topical magnesium and calcium treatment for dermal hydrofluoric acid burns. Ann Emerg Med 1994; 24:9-13.
  • Tomaszewski C, Kirk M, Bingham E, Saltzman B, Cook R, Kulig K:  Urine toxicology screens in drivers suspected of driving while impaired from drugs.  Clin Toxicol 1996; 34:37-44.
  • Goldman MJ, Mowry JB, Kirk MA: Hypertonic sodium bicarbonate to correct ventricular tachycardia in a case of flecainide overdose.  Am J Emerg Med 1997;15:183-186.
  • Burgess JL, Kirk MA, Borron SW, Cisek J:  Emergency department hazardous materials protocol for contaminated patients.  Ann Emerg Med 1999; 34:205-212.
  • Dribben W, Kirk MA, Trippi J, Cordell WC: A pilot study to assess the safety of dobutamine stress echocardiography in the emergency department evaluation of cocaine-associated chest pain. Ann Emerg Med 2001; 38:42-48.
  • Dribben WH, Kirk MA: Organ procurement and successful transplantation after malathion poisoning. J Toxicol Clin Toxicol. 2001;39(6):633-6.
  • Rusyniak D. Furbee R. Kirk M: Thallium and arsenic poisoning in a small midwest town. Ann. Emerg. Med. 2002,39 (3),307-311.
  • Rusyniak D; Kirk M, May J, Kao L, Brizendine E, Welch J, Cordell W, Alonso R: Hyperbaric Oxygen Therapy in Acute Ischemic Stroke: Results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study: Stroke. 2003;34:571-574.
  • Kao L, Kirk M, Evers S, Rosenfeld S: Droperidol, QT Prolongation, and Sudden Death: What Is the Evidence? Ann. Emerg. Med 2003;41:546-558.
  • Rusyniak DE, Kao LW, Nanagas KA, Kirk MA, Furbee RB, Brizendine EJ, Wilmot PE: Dimercaptosuccinic Acid and Prussian Blue in the Treatment of Acute Thallium Poisoning in Rats. Journal of Toxicology—Clinical Toxicology 2003; 41:137-142.
  • Kao LW, Amin Y, Kirk MA, Turner MS: Intrathecal baclofen withdrawal mimicking sepsis. J Emerg Med. 2003 May;24(4):423-7.
  • Kao LK, Kirk MA, Furbee RB, Mehta NH , Skinner JR, Brizendine EJ: What is the rate of adverse events following an intravenous preparation of oral N-Acetylcysteine administered to patients with suspected acetaminophen poisoning?  Ann Emerg Med 2003;42:741-50.
  • Kirk, M.A., M.L. Deaton, and S.P. Frysinger (2003). “Preliminary Report: A Decision Support System for Hazardous Materials Accidents and Terrorism Response.” Critical Infrastructure Protection Project: Workshop I Working Papers (A. Woodcock and K. Thomas, editors). George Mason University Press.
  • Bourne, M.L.G, M. L. Deaton, T.P. Fox, S.P. Frysinger, A.G. Gonzalo, S.D. Kalyani, M.A. Kirk, A.M. VanHorn, and C. G. Williams (2004). “Hazardous Materials Decision Support System:  An Integrated Approach for Prevention, Preparation, and Response to Chemical Accidents and Bioterrorism.” Critical Infrastructure Protection Project: Workshop II Working Papers (A. Woodcock and K. Thomas, editors). George Mason University Press.

 

 

Participation in multicenter trials

  • Brent J, McMartin K, Phillips S, Burkhart KK, Donovan JW, Wells M, Kulig K, Bogdan G, Dart R, Heard K, Kokan L, Akhtar J, Ahsan N, Zimmerman H, Curry S, Wallace K, Aaron C, Burns M, Graudins C, Hartigan S, Hantsch C, Seger D, Berlin R, Douglas D, White S, Kirk M, Hollander J, Ford M, Tomaszewski C, Mckay C: Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med  1999; 340: 832-8.
  • Brent J, McMartin K, Phillips S, Phillips S, Aaron C, Kulig K, Burkhart KK, Donovan JW, Bogdan G, Dart R, Heard K, Wells M, Curry S, Wallace K, Burns M, Graudins C, Hartigan S, Hantsch C, Seger D, Berlin R, Douglas D, White S, Kirk M, Hollander J, Ford M,  Kerns W, Tomaszewski C, , Mckay C, Wax P: Fomepizole for the treatment of methanol poisoning. N Engl J Med  2001; 344: 424-429.

Internet Publications

  • Kirk MA: 2000 case presentation competition case 1, case discussion. Internet Journal of Medical Toxicology. February 2000; vol 4(1).

 

Invited/ Non-Refereed Journals:

  • Kirk M, Cordell W:  Cardiovascular clues to the diagnosis of poisoning. Indiana Medicine 1987; 80: 1158 - 1160.
  • Kirk MA, Burkhart KK, Rumack BH:  The role of the pediatrician in preventing childhood poisoning.  Todays Child 1989; 3: 1-6.
  • Kirk MA:  Poisoning /Overdose:  Therapeutic Intervention.  Acute Care Therapeutics 1989; 4:4-11.
  • Kirk M, Bowers L:  Prehospital management of acute poisoning.  J. Emerg Med Serv, May 1991, p. 64-78.
  • Kirk M, Cisek J, Rose R:  Emergency department response to hazardous materials incidents.  Emerg Med Clinic NA, 1994, 12:461-481.
  • Kirk MA, Pace S: Pearls, pitfalls and updates in toxicology.  Emerg Med Clinic NA 1997, 15: 427-449.
  • Holstege C, Kirk MA: Chemical warfare: Nerve agent poisoning. Critical Care Clinics 1997, 13: 923-942.
  • Holstege CP; Baer , AB ; Kirk MA; Brady WJ. Cardiotoxins. Emerg Med Reports. 2003;24(14):187-198.

 

Abstracts:

  • Kirk M, Voorhees SL, Kulig K, Rumack BH:  Cyanide levels after acetonitrile exposure:  An in vitro study.  Vet Hum Toxicol 1989; 31: 358.
  • Kirk M, Kulig K, Rumack BH:  Acute aldactone overdose resulting in hyperkalemia.  Vet Hum Toxicol 1989; 31: 370.
  • Kirk M, Kulig K, Rumack BH:  Methemoglobin and cyanide kinetics in smoke inhalation.  Vet Hum Toxicol 1989; 31: 370.
  • Kirk MA, Peterson J, Kulig K, Lowenstein S, Rumack BH:  Acetaminophen overdose in children:  A comparison of ipecac versus activated charcoal versus no gastrointestinal decontamination.  Annals of Emergency Medicine, 1991; 20: 472.
  • Kirk M, Selden B, Kulig K:  Serum N-Acetylcysteine levels during hemodialysis.  Vet Hum Toxicol 1992; 34:327.
  • Burkhart K, Brent J, Kirk M, Kulig K, Baker D:  Treatment of dermal hydrofluoric acid burns with topical magnesium and calcium.  Vet Hum Toxicol 1992; 34:344.
  • Burkhart KK, Brent J, Kirk MA, Kulig KW:  The efficacy of magnesium and calcium for the treatment of dermal hydrofluoric acid burns.  Ann Emerg Med 1991; 21:214.
  • Ford M, Tomaszewski C, Kerns W, Rose R, Kirk M, Eichhorst A: Bedside ferric chloride urine test to rule out salicylate intoxication.  Vet Hum Toxicol 1994; 36:364.
  • Kirk M, Olinger M, Mowry J: Medical mass hysteria.  Clin Toxicol 1996; 34:620.
  • Ferry TG, Kirk MA: Chronic salicylate poisoning: A case of mistaken identity. American College of Physicians, Indianapolis , IN Nov 1996.
  • Christianson G, Mowry J, Blashko S, Attwood J, Kirk M, Furbee R: Use of aerosolized sodium bicarbonate to treat household chlorine gas exposure [Abstract]. Clin Toxicology 1997;35:545.
  • Holstege CP, Kirk MA, Furbee RB, Wemuth ME: Wide complex dysrhythmia in calcium channel blocker overdose responsive to sodium bicarbonate therapy.  Clin Toxicology 1998; 36: 509.
  • Dribben W, Kirk MA, Trippi J, Cordell WC: A pilot study to assess the safety of dobutamine stress echocardiography (DSE) in the emergency department evaluation of cocaine-associated chest pain.  Clin Toxicol 1998; 36: 506.
  • Seifert S, Holstege CP, Furbee RB, Kirk MA:  Organ procurement after brodifacoum poisoning.  Clin Toxicol 1998; 36: 463.
  • Dribben W, Welch J, Dunn D, Kirk M. The utilization of emergency department observation units for the poisoned patient. J Toxicol Clin Toxicol 1999;37:586
  • Dribben W, Cappiello H, Kirk M: Successful organ procurement and transplantation from a victim of malathione poisoning. J Toxicol Clin Toxicol 1999; 37: 665.
  • Dribben W, Furbee B, Kirk M: Brainstem infarction and quadriplegia associated with ethylene glycol ingestion. J Toxicol Clin Toxicol 1999; 37: 657
  • Burns D, Snyder L, Kirk M, Mowry J: Rhabdomyolysis from buffalo fish consumption. J Toxicol Clin Toxicol 2000; 38: 513.
  • Christianson G, Mowry J, Kirk M: Hyperkalemia following accidental L-arginine ingestion. J Toxicol Clin Toxicol 2000; 38: 523.
  • Rusyniak D, Furbee B, Kirk M: The coffee pot poisonings: A tale of thallium and arsenic poisoning in a group of automotive workers. J Toxicol Clin Toxicol 2000; 38: 553.
  • Rusyniak D, Dribben W, Furbee B, Kirk M: Survival after massive ingestions of acetaminophen presenting as coma and metabolic acidosis. J Toxicol Clin Toxicol 2000; 38: 569.
  • Dribben WH, Kirk MA: A case of atrial fibrillation associated with GHB ingestion. J Toxicol Clin Toxicol 2001; 39: 315.
  • Snyder LK, Sint T, Kirk MA: Metaxalone induced muscular rigidity. J Toxicol Clin Toxicol 2001; 39: 503.
  • Kirk MA, Mowry JB, Snyder LK, Burns DW: Communications during chaos: A poison center’s role in mass chemical exposure. J Toxicol Clin Toxicol 2001; 39: 538.
  • Rusyniak DE, Kirk MA, May JD, Kao LW, Welch JL, Brizendine EJ, Alonso RJ:  Hyperbaric oxygen treatment in acute ischemic cerebral vascular accidents: A prospective, double-blind, placebo-controlled pilot study.  Academic Emerg Med 2002; 9:445.
  • Kao LW, Kirk MA, Furbee RB, Mehta NH , Skinner JR, Brizendine EJ:  What is the rate of adverse events following intravenous administration of oral N-acetylcysteine in patients with suspected acetaminophen poisoning? Academic Emerg Med 2002; 9:534.
  • Huff JS, Jackson JM, Baer A, Kirk MA: QuickTime movies redux: Improvements in creating an on-line lecture gallery.  Society of Academic Emergency Medicine, May 2003.
  • Kirk MA, Baer AB , Holstege CP. Nasal Button Battery Impaction as Cause of Periorbital Cellulitus and Corrosive Tissue Injury. Clinical Toxicology 2003; 41 (5): 679
  • Holstege CP, Horn JR, Horn SM, Kell SO, Baer AB , Kirk, MA. Survey of First Responder and Health Department Official’s Knowledge of Poison Center Services.  Clinical Toxicology 2003;40(5):697.
  • Holstege CP, Baer AB, Kirk MA. Prolonged Hallucinations Following Ingestion of Alpha-Methyl-Tryptamine. Clinical Toxicology 2003;40(5): 746
  • Kirk MA, Dobmeier SG, Holstege CP, Kell SO: Multiple communications for Poison Centers during mass chemical exposure. Clinical Toxicology 2003;40(5): 746
  • Baer AB , Kirk MA, Holstege CP, Martindale J: Obtaining medical information during a nuclear, biological, or chemical (NBC) incident: A survey study. Clinical Toxicology 2004; 42:820. (abstract)
  • Baer AB , Kirk MA, Eldridge DL, Holstege CP: Profound thrombocytopenia induced by Crotalus Horridus envenomation unresponsive to Crofab. Clinical Toxicology 2004; 42:810. (abstract)
  • Kirk MA, Kell S, Littlewood KE, Eldridge DL, Shukla A, Bell M. Teaching toxicology concepts using human patient simulation. Clinical Toxicology 2004; 42:777. (abstract)
  • Kirk MA, Kell S, Dobmeier S, Baer AB , Holstege CP, Huff JS, Jackson JM: Using new technologies for medical toxicology education. Clinical Toxicology 2004; 42:780. (abstract)
  • Wax P, Nelson L, Seifert SA, Kirk M, McKay C, Clark R, White S, Cetaruk E, Liebelt E, Martin T, Boyer E, Snook CP, Keyes C, Haynes J, Burkhart K, Kosnett M: The ACMT-ATSDR consultation network: first year’s experience. Clinical Toxicology 2004; 42:777. (abstract)
  • Holstege CP, Baer AB , Eldridge DL, Kirk MA, Brady WJ: Case series of elevated troponin I following carbon monoxide poisoning. Clinical Toxicology 2004; 42:742. (abstract)

 

Contributions to Textbooks:

  • Kirk M, Kulig K, Rumack BH:  Anticholinergics, in Haddad and Winchester (Eds):  Clinical Management of Poisoning and Drug Overdose, Ed 2, Philadelphia, PA, W.B. Saunders Company, 1990.
  • Kirk M:  Rational utilization of the intensive care unit in the management of the poisoned patient, in Hoffman RS, Goldfrank LR (Eds):  Contemporary Management in Critical Care.  Churchill Livingston, 1991; 1:3-19.
  • Kirk MA, Tomaszewski CA , Kulig K:  Poisoning in children, In Reisdorff, Robert and  Wiegenstein (Eds):  Pediatric Emergency Medicine. 1st Ed., Philadelphia, PA, W.B. Saunders Co, 1992.
  • Kirk M:  Digitalis Glycosides, in Tintinalli JE, Krome RL, Ruiz E (Eds):  Emergency Medicine: A Comprehensive Study Guide.  4th Edition.  McGraw-Hill Book Company 1996, p 799-802.
  • Kirk M, Rose R:  General pharmacology. In Pons and Cason (Eds): Paramedic Field Care .  Mosby Lifeline, St. Louis , Missouri . 1997.
  • Blackwell T, Kirk M:  Prehospital Medications. In Pons and Cason (Eds): Paramedic Field Care.  Mosby Lifeline, St. Louis , Missouri . 1997.
  • Kirk MA: Anticholinergics and antihistamines in Haddad, Winchester and Shannon (eds): Clinical Management of Poisoning and Drug Overdose, Ed 3, Philadelphia, PA, W.B. Saunders Company, 1998.
  • Kirk MA:  Digitalis poisoning in Rippe JM (Ed):  Intensive Care Medicine, Fourth Edition, Boston , MA .  Little Brown and Company, 1999.  P 1618 - 1624.
  • Dribben W, Kirk M:  Digitalis glycosides, in Tintinalli JE, Krome RL, Ruiz E (Eds):  Emergency Medicine:  A Comprehensive Study Guide.  5th Edition.  McGraw-Hill Book Company 2000. P. 1139-1143.
  • Kirk MA: Care of the chemically contaminated patient in Ford, Delaney, Ling and Rose (eds): Clinical Toxicology, 1st Edition, W. B. Saunders Co, Philadelphia , PA 2001.  p115-126.
  • Marx J, Kirk MA: Chapter 12: Substance Abuse in Harkin (ed) Care of the Surgical Patient.   Scientific American Surgery Spring 1997.
  • Kerns R, Kirk M, Isom G: Cyanide and hydrogen sulfide, In Goldfrank, Flomenbaum, Lewin, Weisman, Howland, and Hoffman (Eds):  Goldrank's Toxicologic Emergencies, 7th Edition. Appleton and Lange, East Norwalk , Conn. 2002.
  • Holstege CP, Kirk M:  Smoke inhalation, In Goldfrank, Flomenbaum, Lewin, Weisman, Howland, and Hoffman (Eds):  Goldrank's Toxicologic Emergencies, 7th Edition. Appleton and Lange, East Norwalk , Conn. 2002.
  • Kirk M:  Use of the intensive care unit in managing the poisoned patient. In Goldfrank, Flomenbaum, Lewin, Weisman, Howland, and Hoffman (Eds):  Goldrank's Toxicologic Emergencies, 7th Edition. Appleton and Lange, East Norwalk , Conn. 2002.
  • Kirk M, Marx JA:  Substance abuse. ACS Surgery: Principles & Practice, section I, chapter 10. Wilmore DW, Souba WW, Fink MP, Eds. WebMD Inc, New York , 2003, www.acssurgery.com
  • Kirk MA, Judge BS:  Cardiac Glycoside Poisoning in Irwin RS and Rippe JM (Eds):  Intensive Care Medicine, Fifth Edition, Boston , MA .  Lippincott Williams and Wilkins, 2003.  P 1455 - 1460.
  • Dribben W, Kirk M: Digitalis Glycosides, in Tintinalli JE, Ruiz E, Krome RL (eds): Emergency Medicine: A Comprehensive Study Guide. 6th Edition. McGraw-Hill Book Company, 2003.
  • Holstege CP; Baer , AB ; Kirk MA; Brady WJ.  Cardiotoxins.  Emergency Medicine Reports.  2003; June 28, 2003 .
  • Baer AB, Kirk MA, Holstege CP.  Organophosphates, carbamates, pesticides, and herbicides.  In Erickson TB, Ahrens WR, Aks SE, Baum CR, Ling LJ (eds): Pediatric Toxicology: Diagnosis and Management of the Poisoned Child. McGraw-Hill Publishing Co. New York , NY . pp. 352-358.  2004.
  • Holstege CP, Kirk M: Digitalis.  In Chan TC, Brady WJ, Harrigan RA, Ornato JP, Rosen P (eds): ECG in Emergency Medicine and Acute Care.  Elsevier-Mosby. Philadelphia PA.   pp. 255-260, 2004.
  • Kirk, MA: Associate Editor. The American Academy of Emergency Medicine Resident and Student Association Toxicology Handbook. Kazzi, ZN and Roberge, RJ editors. 2005.

Submissions

  • Baer AB , Kirk MA: Anticholinergics and antihistamines in Haddad, Winchester and Shannon (eds): Clinical Management of Poisoning and Drug Overdose, Ed 3, Philadelphia , PA, W.B. Saunders Company, 2004.(submitted)
  • Kirk MA, Pope JS: Use of the intensive care unit in managing the poisoned patient. In Goldfrank, et al (eds): Goldfrank’s Toxicologic Emergencies, 8th Edition. Appleton & Lange, East Norwalk , CT.
  • Holstege CP, Kirk M: Smoke inhalation. In Goldfrank, et al (eds): Goldfrank’s Toxicologic Emergencies, 8th Edition. Appleton & Lange, East Norwalk , CT.
  • Holstege CP, Kirk M: Cyanide. In Goldfrank, et al (eds): Goldfrank’s Toxicologic Emergencies, 8th Edition. Appleton & Lange, East Norwalk , CT.
  • Martin-Gill C, Baer AB, Holstege CP, Eldridge DL, Pines J, Kirk MA. Poison centers as information resources for EMS in a suspected chemical exposure. Submitted to J Emerg Med.
  • Gonzalo, A. G., A. M. VanHorn, S. P. Frysinger, M. L. Deaton, and M. A. Kirk (2005). “The FALCON System: Preparing Communities for Weapons of Opportunity .” Journal of Environmental Software and Modeling (in press)