Research: Basic Science
The Division of Medical Toxicology performs basic science research to translate novel findings seen in our clinical practice to the molecular level. In 2006, Dr. Laura Bechtel (image at left) joined our group with a PhD in Pharmacology/Toxicology and an impressive resume of experience. UVa offers a broad availability of laboratory facilities for research project collaboration.
Current and Recent Projects:
- Venom induced thrombocytopenia: Characterization of Timber Rattlesnake venom after binding of Crotalidae Polyvalent immune Fab Antivenom. Wilderness Medicine Society Research in Training Grant, 2009-2010.
- Glucose Uptake Sensitivity in Cardiac vs Skeletal Muscle Cells in Calcium Channel Blocker Toxicity. American Academy of Clinical Toxicology Research Grant. 2007-2009.
- Development and Validation of a LC/MS/MS method to quantitate Salvinorin A and Salvinorin B from human serum and urine samples. This methodology was developed on an ABI 4000 Q Trap at the Chemical Terrorism Lab at the Division of Consolidated Lab Services in Richmond, VA. December 2008.
- Bechtel L., Haverstick D., Holstege C. Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway. Acad Emerg Med. 2008 Apr;15(4):368.
- Cross-Reactivity of False Hellebore Steroid Compounds with a Digoxin Clinical Chemistry Assay. AACT Lampe-Kunkle Memorial Award. 2007-2008.
- Evaluation of variable performance of a Cardiac Troponin I Assay, 2005 -2009. Study Coordinating Center: University of Virginia. 2007-2008.
- Breacher Study. IRB 13070. Study Coordinating Center: University of Virginia. 2008.
- Neoprofen plasma levels in extremely low birth weight infants and their relationship to end-organ blood flow. Study Coordinating Center: University of Virginia: 2007-2009.
- Evaluation of Previously Extracted Viral RNA with the GeneXpert® Enterovirus Assay for use with Samples of Limited Quantity. Travel Award, 2008. Clinical Virology Symposium/ Pan American Society for Clinical Virology.