Path 8300 -- Tumors and the Immune System

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Path 8300 -- Tumors and the Immune System

PATH 8300 Tumor Immunology syllabus review

Required Reading for Introduction:

  1. Summary:

The goal of this class is to provide the student with an in depth analysis of the major aspects of the inter-relationships between the immune system and the tumor.  By the end of the class students should be able to answer the question: why do current immunotherapeutic approaches for cancer fail in the majority of patients?  They should be able to define research avenues that will increase the efficacy of immunotherapies for cancer.

 

  1. Learning Objectives:
    1. To be able to interpret how the processes of immune editing, equilibrium and escape influence the development of neoplasia.
    2. To assess the divergent and convergent roles of myeloid and lymphoid cells in supporting tumor cell growth and metastasis.
    3. To summarize the nature of tumor antigens recognized by innate and adaptive immunity.
    4. To demonstrate how tumors co-opt immunosuppressive components of the immune system to prevent their eradication; how tumors influence their environment.
    5. To be able to devise experimental approaches to ascertain the role of cellular and molecular components of the immune system in the progression and control of cancer.
    6. To be able to analyze experimental results from published articles and synthesize the data into current paradigms about tumor immunology

 

  1. Themes:
  • The contribution of immune cells to tumor progression.
  • Mechanisms of immune-mediated editing of tumors
  • Barriers to tumor immunity that contribute to tumor escape
  • Clinical experiences with tumor immunotherapy

 

  1. Teaching methods:
    1. Each class will be lead by a faculty member.  The faculty member will identify a series of questions for the class.  The faculty member will decide the methods used for each class. At the end of the class, the groups will identify a provocative question that may be used as the basis of the poster (see below).  Each group will present in each class.
    2. 5. Final assignments (Week 12/3-12/5):
    3. Assessments: Students will be graded based on class participation and the final exam.

 

  1. Schedule:

The current schedule is as follows:

Week

Themes

Tuesday


Thursday


1

Overview

22-Oct

Clinical Introduction (Slingluff)

24-Oct

Introduction to Tumor Immunology (Bullock)

2

Sensing

29-Oct

Brown

31-Oct

Bullock (Immunological Cell Death)

3

Editing

5-Nov

Engelhard

7-Nov

Zarling (Adoptive transfer Therapy)

4

Intrinsic regulation

12-Nov

Bullock (Inhibitory receptors)

14-Nov

Tung (Regulatory T cells)

5

Extrinsic Regulation

19-Nov

Cross (MDSC)

21-Nov

Bouton (Tumor Associated Macrophages)

6


26-Nov

Thanksgiving

28-Nov

Thanksgiving

7

Therapeutics

3-Dec

Final Assignments

5-Dec

Final Assignments