Macromolecular Structure and Interactions

SOM Home > Basic Science Departments > Cell & Molecular Biology > Faculty Research Areas > Macromolecular Structure and Interactions

Macromolecular Structure and Interactions


by bushweller


Local Image
A detailed knowledge of the synthesis, structure, function and interactions of macromolecules is a necessity for the full understanding of cellular processes. Numerous researchers at the University of Virginia are involved in state-of-the-art research in these areas. Studies include: the mechanisms of polypeptide chain folding; the three-dimensional configuration of proteins; interactions of proteins with other proteins, nucleic acids and phospholipids; relationship between the plasma membrane and the cytoskeleton and extracellular matrix; and structure-function relations and domain structure of enzymes. Each of these studies includes current technology and instrumentation, including x-ray crystallography, multi-dimensional NMR spectrometry, differential scanning microcalorimetry, fluorescence depolarization, scanning and transmission microscopy and atomic-force microscopy, tandem mass spectrometry, Fourier transform infrared spectrometry, affinity labelin; laser-induced protein/nucleic acid cross-linking, immunofluorescence, hybridoma and recombinant DNA technology, and computer simulation.

Faculty in this area:
  

Nothing to display.


by bushweller


Local Image
A detailed knowledge of the synthesis, structure, function and interactions of macromolecules is a necessity for the full understanding of cellular processes. Numerous researchers at the University of Virginia are involved in state-of-the-art research in these areas. Studies include: the mechanisms of polypeptide chain folding; the three-dimensional configuration of proteins; interactions of proteins with other proteins, nucleic acids and phospholipids; relationship between the plasma membrane and the cytoskeleton and extracellular matrix; and structure-function relations and domain structure of enzymes. Each of these studies includes current technology and instrumentation, including x-ray crystallography, multi-dimensional NMR spectrometry, differential scanning microcalorimetry, fluorescence depolarization, scanning and transmission microscopy and atomic-force microscopy, tandem mass spectrometry, Fourier transform infrared spectrometry, affinity labelin; laser-induced protein/nucleic acid cross-linking, immunofluorescence, hybridoma and recombinant DNA technology, and computer simulation.

Faculty in this area:
  

Nothing to display.