Mark J Yeager, M.D., PhD

Mark J Yeager, M.D., PhD

Andrew P. Somlyo Chair of Molecular Physiology and Biological Physics


Degree(s): M.D., Ph.D.
Graduate School: Yale University School of Medicine and Yale University

Research Interests:
Cardiac Gap Junction Membrane Channels / Integrins Water Channels /  Rotavirus / Reovirus / Retrovirus
Email Address:
Department Phone: 1-434-924-5108
Mobil Phone: 1 858-344-1834
Address: 480 Ray C Hunt Drive / Box 800886/ Charlottesville, Va 22908

Board Certifications: American Board of Internal Medicine, Internal Medicine, 1983   American Board of Internal Medicine, Cardiovascular Disease, 1985

Biography:   Dr. Mark Yeager is a staff cardiologist and Chairman of the Molecular Physiology and Biological Physics Department at The University of Virginia.  Dr. Mark Yeager received his undergraduate degree in chemistry from Carnegie-Mellon University, an M.Phil. and a Ph.D. degree from the Department of Molecular Biophysics and Biochemistry at Yale University and his medical degree from Yale University School of Medicine, where he was elected to Alpha Omega Alpha. His medicine residency, chief residency and specialty training in cardiology were performed at Stanford University Medical Center.

In addition to support from the National Institutes of Health (NIH) and philanthropic grants, Mark Yeager's contributions to biomedical research have been recognized with a Clinical Investigator Award from the NIH, an Established Investigator Award from the American Heart Association and a Clinical Scientist Award in Translational Research from the Burroughs Welcome Fund. Dr. Yeager directs a basic research laboratory examining the structure of macromolecular complexes such as gap junction membrane channels and integrin receptors. Cardiac gap junctions electrically couple adjacent myocardial cells and thereby regulate normal conduction that coordinates the beat-to-beat contraction of the heart but also arrhythmias such as ventricular tachycardia and fibrillation, responsible for more than 250,000 deaths each year. Integrin receptors allow platelets to adhere to one another and participate in normal blood coagulation as well as clots that obstruct blood flow during myocardial infarction. The aim of this work is to gain a deeper understanding of these processes that could lead to new insights for the design of more effective medicines to treat arrhythmias and heart attacks.

Select Publications:


111. Pornillos O, Ganser-Pornillos BK, Yeager M. Atomic-level modelling of the HIV capsid. Nature. 2011 Jan 20;469(7330):424-7. PMID: 21248851

110. Ganser-Pornillos BK, Chandrasekaran V, Pornillos O, Sodroski JG, Sundquist WI, Yeager M. Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):534-9. Epub 2010 Dec 27. PMCID: PMC3021009 

109. Bigler Wang D, Sherman NE, Shannon JD, Leonhardt SA, Mayeenuddin LH, Yeager M, McIntire WE. Binding of β(4)γ(5) by Adenosine A(1) and A(2A) Receptors Determined by Stable Isotope Labeling with Amino Acids in Cell Culture and Mass Spectrometry. Biochemistry. 2010 Dec 17. PMID: 21128647

108. Pornillos O, Ganser-Pornillos BK, Banumathi S, Hua Y, Yeager M. Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus. J Mol Biol. 2010 Sep 3;401(5):985-95. Epub 2010 Jun 26. PMCID: PMC3050670

107. Bennett BC, Yeager M. The lighter side of a sweet reaction. Structure. 2010 Jun 9;18(6):657-9. Review. PMID: 20541500

106. Dryden KA, Crowley CS, Tanaka S, Yeates TO, Yeager M. Two-dimensional crystals of carboxysome shell proteins recapitulate the hexagonal packing of three-dimensional crystals. Protein Sci. 2009 Dec;18(12):2629-35. PMCID: PMC2821281

105. Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M. X-ray structures of the hexameric building block of the HIV capsid.Cell. 2009 Jun 26;137(7):1282-92. Epub 2009 Jun 11. PMCID: PMC2840706

104. Ganser-Pornillos BK, Yeager M, Sundquist WI. The structural biology of HIV assembly. Curr Opin Struct Biol. 2008 Apr;18(2):203-17. Epub 2008 Apr 9. Review. PMCID: PMC2819415

103.Mendez, I.I., Weiner, S.G., She, Y.-M., Coombs, K.M., and Yeager, M. Conformational Changes Accompany Activation of Reovirus RNA-dependent RNA Polymerase. J Struct Biol. 2008 May;162(2):277-89. Epub 2008 Jan 26. PMCID: PMC2819412

102. Yeager, M. and Harris. A. L. Gap Junction Channel Structure in the Early Twenty-first Century: Facts and Fantasies. Curr Opin Cell Biol. 2007 Oct;19(5):521-8. PMCID: PMC2819411

101.Ganser-Pornillos, B. and Yeager, M. Structure of Full-length HIV-1 CA: A Model for the Mature Capsid Lattice. Cell. 2007 Oct 5;131(1):70-9 PMID: 17923088

100.Manayani, D.J., Thomas, D., Dryden, K., Reddy, V., Siladi, M.E., Marlett, J.M., Rainey, G.J.A., Pique, M., Scobie, H.M., Yeager, M., Young, J.A.T., Manchester, M., and Schneemann, A. A Viral Nanoparticle With Dual Function as an Anthrax Antitoxin and Vaccine. PLoS Pathog. 2007 Oct 5;3(10):1422-31 PMCID: PMC2000967

99. Hanson, M.A., Brooun, A., Roth, C., Jaakola, V.-P., Chien, E., Alexandrov, A., Velasquez, J., Davis, L., Griffith, M., Moy, K., Baker, K.A., Ganser-Pornillos, B., Hua, Y., Kuhn, P. Ellis, S., Yeager, M., and Stevens, R.C. Profiling of Membrane Protein Variants in a Baculovirus System by Coupling Cell-surface Detection with Small-scale Parallel Expression. Protein Expr Purif. 2007 Nov;56(1):85-92 PMCID: PMC2274776

98.  Kovacs, J.A., Yeager, M., and Abagyan, R. Computational Protocol for the Prediction of the Atomic-resolution Structures of Helical Membrane Proteins Aided by EM Maps. Biophys J. 2007 Sep 15;93(6):1950-9 PMCID: PMC1959528

97.  Russo, R.S., Silva, P., and Yeager, M. Coronary Artery Over-expansion Increases Neointimal Hyperplasia after Stent Placement. Heart. 2007 Dec;93(12):1609-15 PMID: 17639098

96.  Adair, B.D. and Yeager, M. Electron Microscopy of Integrins. Methods Enzymol. 2007;426:337-73. PMID: 17697891

95.  Dryden, K.A., Coombs, K., and Yeager, M. The Structure of Orthoreoviruses. In: Structure and Molecular Biology of Segmented Double-Stranded RNA Viruses, Patton, J., Ed. Horizon Scientific Press, Wymondham, Norfolk United Kingdom

94.  Kovacs, J.A., Baker, K.A., Altenberg, G. A., Abagyan, R., and Yeager. M. Molecular Modeling and Mutagenesis of Gap Junction Channels.  Prog. Biophys. Mol. Biol. 94: 15-28 (2007). PMID: 17524457

93.  Kovacs, J.A., Abagyan, R., and Yeager, M. Fast Bessel Matching. J. Comput.Theor. Nanosci. 4:  84-95 (2007).

92.  Cheng, A. and Yeager, M. Bootstrap Resampling for Voxel-wise Variance Analysis of Three-dimensional Density Maps Derived by Image Analysis of Two-dimensional Crystals. J. Struct. Biol. 158: 19-32 (2007). PMID: 17187989

91.  Ren, G., Gao, K., Bushman, F., and Yeager, M. Single Particle Image Reconstruction of a Tetramer of HIV Integrase Bound to DNA. J. Mol. Biol. 366: 286-294 (2007). PMCID: PMC1855144

90.  Neuman, B.W., Adair, B.D., Yoshioka, C., Quispe, J.D., Milligan, R.A., Yeager, M., and Buchmeier, M.J. Ultrastructure of SARS-CoV, FIPV and MHV Revealed by Electron Cryomicroscopy. Adv. Exp. Med. Biol. 581: 181-185 (2006). PMID: 17037527



89.  Craig, L., Volkmann, N., Arvai, A.S., Pique, M.E., Yeager, M., Egelman, E.H., and Tainer, J. A. Type IV Pilus Structure by Cryo-Electron Microscopy and Crystallography: Implications for Pilus Functions in Pathogenicity. Mol. Cell 23: 651-662 (2006). [featured on the cover] PMID: 16949362

88.  Neuman, B.W. Adair, B.D., Yoshioka, C. Quispe, J.D., Orca, G., Kuhn, P., Milligan, R.A., Yeager, M. and Buchmeier, M.J. Supramolecular Architecture of SARS Coronavirus Revealed by Electron Cryomicroscopy. J. Virol. 80: 7918-7928 (2006). PMID: 16873249



87.  Dryden, K.A., Wieland, S.F., Whitten-Bauer, C., Chisari, F.V., and Yeager, M. Native Hepatitis B Virions and Capsids Visualized by Electron Cryo-microscopy. Mol. Cell 22: 843-850 (2006). [featured on the cover] PMID: 16793552




86.  Greig, S. L., Berriman, J.A., O=Brien, J.A., Taylor, J.A., Bellamy, A.R., Yeager, M., and Mitra, A.K. Structural Determinants of Rotavirus Subgroup Specificity Mapped by Cryo-Electron Microscopy. J. Mol. ref.86.gifBiol. 356: 209-221 (2006). [featured on the cover] PMID: 16359700


85.  Daniels, M.J., Wood, M. and Yeager, M. In vivo Functional Assay of a Recombinant Aquaporin in Pichia Pastoris. Applied and Environmental Microbiol. Applied and Environmental Microbiol. 72: 1507-1514 (2006). PMCID: PMC1392912


84.  Daniels, M.J. and Yeager, M. Phosphorylation of Aquaporin PvTIP3;1 Defined by Mass Spectrometry and Molecular Modeling. Biochemistry 44: 14443-144454 (2005). PMID: 16262244

83.  Wiedenheft, B., Mosolf, J., Willits, D., Yeager, M., Dryden, K., Young, M., and Douglas, T. An archaeal antioxidant: Characterization of a Dps-like protein from Sulfolobus solfataricus. Proc. Natl. Acad. Sci. USA 102: 10551-10556 (2005). PMCID: PMC1175829

82.  Gollapudi, R.R., Yeager, M., Johnson, A.D. Left Ventricular Cardiac Tamponade in the Setting of Cor Pulmonale and Circumferential Pericardial Effusion:  Case Report and Review of the Literature.  Card. Rev. 13: 214-217 (2005). PMID: 15949058

81.  Adair, B.D., Xiong, J.-P., Maddock, C., Goodman, S.L., Arnaout, M.A., and Yeager, M. Three-dimensional EM Structure of the Ectodomain of Integrin αVβ3 in Complex with Fibronectin. J. Cell Biol. 168: 1109-1118 (2005). PMCID: PMC2171847



ref-80.gif80.  Neuman, B.W., Adair, B.D., Burns, J.W., Milligan, R.A., Buchmeier, M.J., and Yeager, M. Complementarity in the Supramolecular Design of Arenaviruses and Retroviruses Revealed by Electron Cryo-microscopy and Image Analysis J. Virol. 79: 3822-3830 (2005) [featured on the cover]. PMCID: PMC1075687




79.  Turbedsky, K.T., Pollard, T.D. and Yeager, M. Assembly of Acanthamoeba Myosin-II Minifilaments. Model of Anti-parallel Dimers Based on EM and X-ray Diffraction of 2D and 3D Crystals.  J. Mol. Biol. 345: 363-373 (2005) [featured on the cover]. PMID: 15571728







78.  Becker, C.F., Strop, P., Bass, R.B., Hansen, K.C., Locher, K.P., Ren, G., Yeager, M., Rees, D.C., and Kochendoerfer, G.G. Conversion of a Mechanosensitive Channel to a Water-soluble Form by Covalent Modification with Amphiphiles. J. Mol. Biol. 343: 747-758 (2004) [featured on the cover]. PMID: 15465059



77.  Fleishman, S.J., Unger, V.M., Yeager, M., and Ben-Tal, N. A Cα Model for the Transmembrane α-helices of Gap Junction Intercellular Channels. Mol. Cell 15: 879-888 (2004). PMID: 15383278

76.  Cheng, A. and Yeager, M. A Graphical Representation of Image Quality for Three-dimensional Structure Analysis of Two-dimensional Crystals. Acta Cryst. A. 60: 351-354 (2004). PMID: 15218215

75.  Brill, L.M., Dechongkit, S., DeLaBarre, B., Stroebel, J., Beachy, R.N. and Yeager, M. Dimerization of Recombinant TMV Movement Protein. J. Virol. 78: 3372-3377 (2004). PMCID: PMC371043


74.  Tihova, T., Dryden, K., Thuv-vy, L.L., Harvey, S.C., Johnson, J.E., Yeager, M. and Schneemann, A. Nodavirus Coat Protein Imposes Dodecahedral RNA Structure Independent of Nucleotide Sequence and Length. J. Virol.78: 2897-2905 (2004) [featured on the cover]. PMCID: PMC353755



73.  Granville, D.J., Tashakkor, B., Takeuchi, C., Gustafsson, Å.B., Huang, C., Sayen, M.R., Wentworth,P. Jr., Yeager, M., and Gottlieb, R.A. Reduction of Ischemia and Reperfusion-induced Myocardial Damage by Cytochrome P450 Inhibitors. Proc. Natl. Acad. Sci. USA 101: 1321-1326 (2004). PMCID: PMC337051

72.  Oshima, M., Muriaux, D., Mirro, J., Nagashima, K., Dryden, K., Yeager, M., and Rein, A. Effects of Blocking Individual Maturation Cleavages in Murine Leukemia Virus GAG. J. Virol. 78: 1411-1420 (2004). PMCID: PMC321369

71.  Cheng, A., Schweissinger, D., Dawood, F., Kumar, N. and Yeager. M. Projection Structure of Full Length Connexin 43 by Electron Cryo-crystallography. Cell Comm. Adh. 10:187-191 (2003). PMID: 14681014

70.  Ganser, B.K., Cheng, A., Sundquist, W.I., and Yeager, M. Three-dimensional Structure of the M-MuLV CA Protein on a Lipid Monolayer: A General Model for Retroviral Capsid Assembly. EMBO J. 22:  2886-2892 (2003). PMCID: PMC162131

69.  Craig, L., Taylor, R.K., Pique, M.E., Adair, B.D., Arvai, A.S., Singh, M., Lloyd, S.J., Shin, D.S., Getzoff, E.D., Yeager, M., Forest, K.T., and Tainer, J.A. Type IV Pilin Fold and Assembly Based on X-ray Crystallographic and EM Analyses of Vibrio cholerae Toxin Coregulated Pilus and Pseudomonas aeruginosa AK Pilin. Mol. Cell 11:1139-1150 (2003). PMID: 12769840

68.  Adair, B.D. and Yeager, M. Three-dimensional Model of the Human Platelet Integrin αIIbβ3 Based on Electron Cryo-Microscopy and X-ray Crystallography. Proc. Natl. Acad. Sci USA 99:14059-14064 (2002). PMCID: PMC137836

67.  Grise, M.A., Yeager, M.J., and Teirstein, P.S. A Case of an Entrapped Rotational Atherectomy Burr. Catheter. Cardiovasc. Interv. 57:31-33 (2002). PMID: 12203923

66.  Brugidou, C.,Opalka, N., Yeager, M., Beachy, R.N., and Fauquet, C. Stability of RiceYellow Mottle Virus (RYMV) and Cellular Compartmentalization During the Infection Process in Oryza sativa. Virology 297: 98-108(2002). PMID: 12083840



65.  Tang, L., Lin, C.S., Krishna, N.K., Yeager, M., Schneemann, A., and Johnson, J.E. Virus-like Particles of a Fish Nodavirus Display a Capsid Subunit Domain Organization Different from Insect Nodaviruses. J. Virol, 76: 6370-6375 (2002) [featured on the cover]. PMCID: PMC136213


64.  Yeager, M. and Unger, V.M. Culturing of Mammalian Cells Expressing Recombinant Connexins and Two-Dimensional Crystallization of the Isolated Gap Junctions. In: Connexin Methods and Protocols, Methods in Molecular Biology, Bruzzone, R. and Giaume C., Eds. Humana Press Inc., Totowa, NJ., volume 154, pp. 77-89 (2001). PMID: 11218666

63.  Tihova, M., Dryden, K.A., Bellamy, A.R., Greenberg, H.B., and Yeager, M. Localization of Membrane Permeabilization and Receptor Binding Sites on the VP4 Hemagglutinin of Rotavirus: Implications for Cell Entry. J. Mol. Biol. 314: 985-992 (2001) [featured on the cover]. PMID: 11743716

62.  Nunn, R.S., Macke, T.J., Olson, A.J., and Yeager, M. Transmembrane α-helices in the Gap Junction Membrane Channel: Systematic Search of Packing Models Based on the Pair Potential Function. Microsc. Res. and Tech. 52: 344-351 (2001). PMID: 11180625

61.  Tang, L., Johnson, K.N., Ball, L.A., Lin, T., Yeager, M., and Johnson, J.E. The Structure of Pariacoto Virus Reveals a Dodecahedral Cage of Duplex RNA. Nature Struct. Biol. 8: 77-83 (2001). PMID: 11135676

60.  Saffitz, J.E. and Yeager, M. Intracardiac Cell Communication and Gap Junctions. In: Foundations of Cardiac Arrhythmias, Spooner, P.M. and Rosen, M.R., Eds. Marcel Dekker, Inc., New York. pp. 171-205 (2001).

59.  Yeager, M. and Nicholson, B.J. Structure and Biochemistry of Gap Junctions. In: Gap Junctions, Advances in Molecular and Cell Biology, Hertzberg, E., Ed. JAI Press., volume 30, pp. 31-98 (2000).

58.  Qu, C., Liljas, L., Opalka, N., Brugidou, C., Yeager, M., Beachy, R.N., Johnson, J.E., and Lin, T. 3D Domain Swapping Modulates the Stability of Members of an Icosahedral Virus Group. Structure 8: 1095-103 (2000). PMID: 11080631

57.  Opalka, N., Tihova, M., Brugidou, C., Kumar, A., Beachy, R.N., Fauquet, C.M., and Yeager, M. Structure of Native and Expanded Sobemoviruses by Electron Cryo-microscopy and Image Reconstruction. J. Mol. Biol. 303:197-211 (2000). PMID: 11023786

56.  Canady, M.A., Tihova, M., Hanslik, T.N., Johnson, J.E., and Yeager, M. Large Conformational Changes in the Maturation of a Simple RNA Virus, Nudaurelia capensis ω Virus (NωV). J. Mol. Biol. 299: 573-584 (2000) [featured on the cover]. PMID: 10835268

55.  Brill, L.M., Nunn, R.S., Kahn, T.W., Yeager, M., and Beachy, R.N. Recombinant Tobacco Mosaic Virus Movement Protein is an RNA-binding, α-helical Membrane Protein. Proc. Natl. Acad. Sci. USA 97: 7112-7117 (2000). PMCID: PMC16508

54.  Yeager, M. Molecular Biology and Structure of Cardiac Gap Junction Intercellular Channels.  In: Cardiac Electrophysiology: From Cell to Bedside, 3rd edition, Zipes, D. and Jalife, J., Eds. W.B. Saunders Co. pp. 31-40 (1999).

53.  Yeager, M., Unger, V.M., and Mitra, A.K. Three-Dimensional Structure of Membrane Proteins Determined by Two-Dimensional Crystallization, Electron Cryomicroscopy, and Image Analysis. Methods in Enzymol. 294: 135-180 (1999).

52.  Unger, V.M., Kumar, N.M., Gilula, N.B., and Yeager, M. Expression, Two-dimensional Crystallization, and Electron Cryo-crystallography of Recombinant Gap Junction Membrane Channels. J. Struct. Biol.128: 98-105 (1999).

51.  Unger, V.M., Kumar, N.M., Gilula, N.B., and Yeager, M. Three-dimensional Structure of a Recombinant Gap Junction Membrane Channel. Science 283: 1176-1180 (1999) [featured on the cover].

50.  Unger, V.M., Kumar, N.M., Gilula, N.B., and Yeager, M. Electron Cryo-Crystallography of a Recombinant Gap Junction Channel at 7Å Resolution. In: Gap Junction-Mediated Intercellular Signalling in Health and Disease, Novartis Foundation, John Wiley and Sons, New York. pp. 22-37 (1999).

49.  Daniels, M.J., Chrispeels, M.J. and Yeager, M. Projection Structure of a Plant Vacuole Membrane Aquaporin by Electron Cryo-crystallography. J. Mol. Biol. 294: 1337-1349 (1999).

48.  Yeager, M., Wilson-Kubalek, E.M., Weiner, S.G., Brown, P.O., and Rein, A. Supramolecular Organization of Immature and Mature Murine Leukemia Virus Revealed by Electron Cryo-Microscopy:  Implications for Retroviral Assembly Mechanisms. Proc. Natl. Acad. Sci. USA 95: 7299-7304 (1998).

47.  Yeager, M., Unger, V.M., and Falk, M.M. Synthesis, Assembly and Structure of Gap Junction Intercellular Channels. Curr. Op. Struct. Biol. 8: 517-524 (1998).

46.  Yeager, M. Structure of Cardiac Gap Junction Intercellular Channels.  J. Struct. Biol. 121: 231-245 (1998).

45.  Opalka, N., Brugidou, C., Bonneau, C., Nicole, M., Beachy, R.N., Yeager, M., and Fauquet, C. Movement of Rice Yellow Mottle Virus Between Xylem Cells Through Pit Membranes. Proc. Natl. Acad. Sci. USA 95: 3323-3328 (1998).

44.  Yeager, M. Structure of Cardiac Gap Junction Membrane Channels: Progress Toward a Higher Resolution Model.  In: Discontinuous Conduction in the Heart, Spooner, P.M., Joyner, R.W. and  Jalife, J., Eds. Futura. Armonk, NY. pp. 161-184 (1997).

43.  Unger, V.M., Kumar, N.M., Gilula, N.B., and Yeager, M. Projection Structure of a Gap Junction Channel at 7Å Resolution. Nature Struct. Biol. 4: 39-43 (1997).

42.  Hsu, G., Bellamy, A.R., and Yeager, M. Projection Structure of VP6, the Rotavirus Inner Capsid Protein, and Comparison with Bluetongue VP7. J. Mol. Biol. 272: 362-368 (1997).

41.  Cheng, A., van Hoek, A.N., Yeager, M., Verkman, A.S., and Mitra, A.K. Three-dimensional Organization in a Human Water Channel. Nature 367: 627-630 (1997).

40.  Yeager, M. and Nicholson, B.J. Structure of Gap Junction Intercellular Channels. Curr. Op. Struct. Biol. 6:  183-192 (1996).

39.  Taylor, J.A., O'Brien, J.A., and Yeager, M. The Cytoplasmic Tail of NSP4, the Endoplasmic Reticulum-localized Non-structural Glycoprotein of Rotavirus, Contains Distinct Virus Binding and Coiled Coil Domains. EMBO J. 15: 4469-4476 (1996) [featured on the cover].

38.  Siuzdak, G., Bothner, B., Yeager, M., Brugidou, C., Fauquet, C.M., Hoey, K., and Chang, C.-M. Viral Mass Spectrometry. Chem. and Biol. 3: 45-48 (1996).

37.  Sheehan, B., Fuller, S.D., Pique, M.E., and Yeager, M. AVS Software for Visualization in Molecular Microscopy. J. Struct. Biol. 116: 99-106 (1996).

36.  Yeager, M. Electron Microscopic Image Analysis of Cardiac Gap Junction Membrane Crystals. Microsc. Res. and Tech. 33: 452-466 (1995).

35.  Mitra, A.K., van Hoek, A.N., Wiener, M.C., Verkman, A.S., and Yeager, M. The CHIP28 Water Channel Visualized in Ice by Electron Crystallography. Nature Struct. Biol. 2: 726-729 (1995).

34.  Yeager, M., Berriman, J.A., Baker, T.S., and Bellamy, A.R. Three-dimensional Structure of the Rotavirus Haemagglutinin VP4 by Cryo-electron Microscopy and Difference Map Analysis. EMBO J. 13: 1011-1018 (1994) [featured on the cover].

33.  Yeager, M. In situ Two-dimensional Crystallization of a Polytopic Membrane Protein:  The Cardiac Gap Junction Channel. Acta. Cryst. D50: 632-638 (1994).

32.  Mitra, A.K., Yeager, M. van Hoek, A.N., Wiener, M.C., and Verkman, A.S. Projection Structure of the CHIP28 Water Channel in Lipid Bilayer Membranes at 12Å Resolution. Biochemistry 33: 12735-12740 (1994).

31.  Yeager, M. Structure and Design of Cardiac Gap-Junction Membrane Channels. In: Gap Junctions, Hall, J.E., Zampighi, G.A. and Davis, R.M., Eds.  Elsevier.  New York.  pp. 47-55  (1993).

30.  Dryden, K.A., Wang, G., Yeager, M., Nibert, M.L., Furlong, D.B., Coombs, K.M., Fields, B.N., and Baker, T.S. Early Steps in Reovirus Infection are Associated With Dramatic Changes in Supramolecular Structure and Protein Conformation:  Analysis of Virions and Subviral Particles by Cryoelectron Microscopy and Three-dimensional Image Reconstruction.  J. Cell Biol. 122: 1023-1041 (1993) [featured on the cover].

29.  Yeager, M. and Gilula, N.B. Membrane Topology and Quaternary Structure of Cardiac Gap Junction Ion Channels. J. Mol. Biol. 223: 929-948 (1992) [featured on the cover].

28.  Yeager, M., Dryden, K.A., Olson, N.H., Greenberg, H.B., and Baker, T.S. Three-dimensional Structure of Rhesus Rotavirus by Cryoelectron Microscopy and Image Reconstruction. J. Cell Biol. 110: 2133-2144 (1990) [featured on the cover].

Yeager, M. In: Handbook of Difficult Diagnosis.  Louis, A.A. (ed).  New York:  John Churchill Livingstone (1990).Chapters 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 70 and 94.

27.  Ch. 94 Hypertension:  Renovascular and Other Secondary Causes, pp. 669-675. (coauthored with Dr. Sylvestre Quevedo.)

26.  Ch. 70 Hypothermia:  Causes and Associated Disorders, pp. 508-513.

25.  Ch. 11 Aortoarterial Emboli:  Cardiac and Noncardiac Sources, pp. 68-74.

24.  Ch. 10 Cervical Sounds: Conditions that Can Mimic Carotid Bruits, pp. 64-67.

23.  Ch. 9  Bloody Pericardial Effusions:  Major Causes, pp. 62-63.

22.  Ch. 8  Acute Pericarditis:  Common and Less Common Causes, pp. 54-61.

21.  Ch. 7  Cardiac Arrhythmias:  Cardiac and Noncardiac Causes, pp. 43-54.

20.  Ch. 6  Cardiomegaly:  a Differential Diagnosis, pp. 37-43.

19.  Ch. 5  Congestive Heart Failure:  Major Etiologic Categories, pp. 29-36.

18.  Ch. 4  ECG Patterns:  Disorders That Can Simulate Myocardial Ischemia and Infarction, pp. 24-29.

17.  Ch. 3  Angina-like Chest Pain:  Cardiac and Noncardiac Causes, pp. 15-23.

16.  Ch. 2  Coronary Artery Insufficiency and Myocardial Infarction:  Nonatherosclerotic Causes, pp. 9-15.

15.  Ch. 1  Atherosclerotic Coronary Disease:  Risk Factors, pp. 3-8.

14.  Yeager, M., Yock, P.G., and Popp, R.L. Comparison of Doppler-derived Pressure Gradient to That Obtained at Cardiac Catheterization in Adults With Aortic Valve Stenosis:  Implications for Management. Amer. J. Cardiol. 57: 644-648 (1986).

13.  Teirstein, P., Yeager, M., Yock, P.G., and Popp, R.L. Doppler Echocardiographic Measurement of Aortic Valve Area in Aortic Stenosis: A Non-invasive Application of the Gorlin Formula. J. Amer. Coll. Cardiol. 8: 1059-1065 (1986).

12.  Yeager, M. Outlines in Internal Medicine -- A Guide to Decisions on Diagnosis and Management (1985).  (266 page textbook written for Stanford housestaff and medical students during Chief Residency 1982-83.)

11.  Jacobs, M.B. and Yeager, M. Thrombotic and Infectious Complications of Hickman-Broviac Catheters. Arch. Intern. Med. 144: 1597-1599 (1984).

10.  Yeager, M. Indications for Digoxin Therapy for Congestive Heart Failure. West. J. Med. 138: 712 (1983).

9.  Yeager, M., Schoenborn, B., Engelman, D., Moore, P., and Stryer, L. Neutron Diffraction Analysis of the Structure of Rod Photoreceptor Membranes in Intact Retinas. J. Mol. Biol. 137: 315-348 (1980).

8.  Yeager, M. Neutron Diffraction Analysis of the Structure of Rod Photoreceptor Membranes in Intact Retinas.  Ph.D. thesis, Yale University, New Haven, CT (1978).

7.  Yeager, M.J. Neutron Diffraction Analysis of the Structure of Retinal Photoreceptor Membranes and Rhodopsin. Brookhaven. Symp. Biol. 27(Ch.III): 3-27 (1975).

6.  Yeager, M.J. Data Analysis of Low-angle Diffraction by One-dimensional Crystals. Brookhaven Symp. Biol. 27(Ch.VII): 77-106 (1975).

5.  Hershfield, R., Yeager, M.J., and Schmir, G.L. Mechanism of Hydrolysis of an Unsymmetrical Ketene O,O-acetal and of Ketene O,S-acetals. J. Org. Chem. 40: 2940-2946 (1975).

4.  Yeager, M. Investigation of Polypeptide Chain Folding Using Fluorescence Energy Transfer. M.Phil. research proposal, Yale University, New Haven, CT (1973).

3.  Yeager, M.J. and Kohman, T.P. Search For Natural Radioactivity of Calcium-48. USAEC Report No. NYO-844-84: 48-53 (1971).

2.  Yeager, M. Conceptual Change and Education. Carnegie Tech. 35: 7-11 (1971).

1.  Yeager, M.J. and Kohman, T.P. Search For Natural Radioactivity of Calcium-48. USAEC Report No. NYO-844-81: 57-64 (1970).