Jim Cronk

Jim Cronk

JimC 

I graduated from the University of Colorado, Boulder 2008, and am currently a student in the UVA MSTP and Neuroscience Graduate Program. Using mouse models of Rett syndrome, a neurodevelopmental disease caused by mutations of the methyl-CpG binding protein MeCP2, I am studying the role of tissue-resident macrophages in nervous and immune system development and homeostasis. I am trying to understand how tissue-resident macrophages can ameliorate progression of Rett syndrome, and identify the downstream molecular events and cellular targets that underlie the beneficial effect of immunity and glia in Rett. I also study MeCP2-duplication syndrome, a disease in which patients suffer from recurrent, sometimes lethal, respiratory infections. I am investigating the immune response to respiratory infection in a mouse model of MeCP2-overexpression, and attempting to identify what goes wrong and how we might treat patients to alleviate both recurrence of infection and mortality.

Email:  jcc2cm@virginia.edu