Jason P. Sheehan, M.D., Ph.D.

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Jason P. Sheehan, M.D., Ph.D.

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Professor of Neurological Surgery and Neuroscience
Co-Director of the Lars Leksell Gamma Knife Center

B.S.     1992    Chemical Engineering, University of Virginia
M.S.    1992    Biomedical Engineering, University of Virginia
Ph.D.   1997    Biological Physics, University of Virginia
M.D.    1998    University of Virginia

Epilepsy and Neuronal Regeneration Research Strategies

My laboratory is focused on two major research areas.  The first involves the study of the underlying mechanisms by which stereotactic radiosurgery ameliorates seizures.  A multicenter NIH study using Gamma Knife surgery has demonstrated the efficacy of subnecrotic doses of radiation to the amygdala and hippocampal structures of patients with temporal lobe epilepsy.  Moreover, research completed at the University of Virginia using a chronic temporal lobe epilepsy animal model has shown a similarly positive result.  This animal model has demonstrated changes in hippocampal neuronal circuitry that is likely the cause of the improvement in epilepsy.  The Gamma Knife induced neuromodulation is the subject of intense research by our lab in conjunction with Dr. Kevin Lee.

The other area of active research is the study of axonal guidance cues in a human neuronal model.  Human neurons from epilepsy patients and a brain tumor cell line are being investigated.  The guidance cues (e.g. Nogo) and intracellular calcium signaling that facilitate or inhibit axonal propagation are targets of interest in this in vitro research.

Representative Publications

Sheehan J, Sun MH, Kondziolka D, Flickinger J, Lunsford L:  Radiosurgery in Patients with Renal Cell Carcinoma Metastasis to the Brain:  Long-Term Outcomes and Prognostic Factors Influencing Survival and Local Tumor Control.  Journal of Neurosurgery 98:342-349, 2003.

Sheehan JP, Sheehan JM, Seeherman H, Quigg M, Helm GA:  The Safety and Utility of Recombinant Bone Morphogenetic Protein-2 for Cranial Procedures in a Nonhuman Primate Model.  Journal of Neurosurgery 98:125-130, 2003.

Sheehan J, Niranjan A, Kondziolka D:  Ex Vivo Gene Therapy and Cell Therapy for Stroke, In Progress in Neurosurgery:  Molecular Neurosurgery, Janson C, ed, Karger, 2002.

Sheehan JP, Sheehan JM, Holmberg EG, Geisert EE, Helm GA :  A Horseradish Peroxidase-Light and Electron Microscopic Study of Immunoliposomes Utilized for Intracellular Delivery to the Rat Striatum.  Neuroscience Letters 333(3):212-216, 2002.

Swerdlow RH, Parks JK, Cassarino DS, Trimmer PA, Miller SW, Maguire DJ, Sheehan JP, Maguire RS, Pattee G, Juel VC, Phillips LH, Tuttle JB, Bennett JP, Davis RE, Parker WD Jr:  Mitochondria in Sporadic Amyotrophic Lateral Sclerosis. Experimental Neurology 153(1):135-142, 1998.

Swerdlow R, Parks J, Miller S, Tuttle J, Trimmer P, Sheehan J, Bennett J, Davis R, Parker WD:  Origin and Functional Consequences of the Complex I Defect in Parkinson's Disease.  Annals of Neurology 40(4):663-671, 1996.

Helm GA , Sheehan JM, Sheehan JP, Jane JA Jr., diPierro CG, Simmons NE , Gillies GT, Kallmes DF, Sweeney TM:  Utilization of Type I Collagen Gel, Demineralized Bone Matrix and Bone Morphogenetic Protein-2 (rhBMP-2) to Enhance Autologous Bone Lumbar Spinal Fusion.  Journal of Neurosurgery 86:93-100, 1997.

Sheehan J, Swerdlow R, Parker W, Tuttle J:  Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease.  Journal of Neurochemistry 68(3):1221-1233, 1997.

Sheehan J, Palmer P, Helm G, Tuttle J:  MPP+ Induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells:  An Electron Microscope Study.  Journal of Neuroscience Research 48(3):226-237, 1997.

PubMed Link to Sheehan Publications