Selected Publications:

Roller D, Axelrod M, Kew M, Holmberg K, Janes K, Jensen P, Papin J, Capaldo B, Mackey A, Weber MJ, and D Gioeli*. Selection of combinatorial therapeutic targets for melanoma identified by synthetic lethal screening with small molecule inhibitors. Molecular Cancer Therapeutics. 2012 Nov;11(11):2505-15. PMC3496043

Whitworth H, Bhadel S, Ivey M, Conaway M, Spencer A, Hernan R, Holemon H and D Gioeli. Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen. PLoS ONE. 7(6):e38950. PMC3384611

Gioeli D, Wunderlich W, Sebolt-Leopold J, Bekiranov S, Wulfkuhle J, Petricoin EF, Conaway M, and Weber MJ. Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration resistant prostate cancer. Molecular Cancer Therapeutics. 2011 10(9):1581-90. PMID: 21712477

Cinar B, Kisaayak Collak F, Lopez D, Akgul S, Mukhopadhyay NK, Kilicarslan M, Gioeli D, Freeman MR. MST1 is a Multifunctional Caspase-Independent Inhibitor of Androgenic Signaling. Cancer Research. 2011 71(12):4303-431. PMID: 21512132

Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA, Shabanowitz J , Hunt DF, Xenarios I, Hahn WC, Conaway M, Carey MF, and D Gioeli. CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. Molecular Endocrinology. 2010 24(12): 2267-2280. PMID: 20980437

Tilghman RW, Cowan C, Mih J, Koryakina Y, Gioeli D, Slack-Davis J, Blackman B, Tschumperlin D, Parsons JT. Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One. 2010 5(9). PMID: 20886123

Liu Y, Karaca M, Zhang Z, Gioeli D, Earp HS, Whang YE. Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases. Oncogene. 2010 3;29(22):3208-16. PMID: 20383201

Ni L, Yang CS, Gioeli D, Frierson H, Toft DO, Paschal BM. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Molecular and Cellular Biology. 2010 30(5):1243-53. PMID: 20048054

DaSilva J, Gioeli D, Weber MJ, Parsons SJ. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Research. 2009 69(18):7402-11. PMID: 19706771

Kaikkonen S, Jääskeläinen T, Karvonen U, Rytinki MM, Makkonen H, Gioeli D, Paschal BM, and Palvimo JJ. SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells. Molecular Endocrinology. 2009. 23(3):292–307. PMID: 19116244

Kesler CT, Gioeli D, Conaway M, Weber MJ, Paschal BM. Subcellular Localization Modulates AF-1 Domain Phosphorylation in the Androgen Receptor. Molecular Endocrinology. 2007. 21(9):2071-84. PMID: 17579212

Kraus S, Gioeli D, Vomastek T, Gordon V, and Weber MJ. RACK1 and Src Regulate the Tyrosine Phosphorylation and Function of the Androgen Receptor. Cancer Research. 2006; 66(22): 11047-11054. PMID: 17108144

Gioeli D, Black B, Gordon V, Spencer A, Kesler CT, Eblen ST, Paschal BM, Weber MJ. Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization. Molecular Endocrinology. 2006; 20(3): 503-515. PMID: 16282370

Yang C, Vitto MJ, Busby SA, Garcia BA, Kesler CT, Gioeli D, Shabanowitz J, Hunt DF, Rundell K, Brautigan DL, Paschal BM. SV40 Small t Antigen Mediates Conformation-Dependent Transfer of Protein Phosphatase 2A (PP2A) onto the Androgen Receptor. Molecular and Cellular Biology. 2005; 25: 1298-1308. PMID: 15684382

Fu M, Rao M, Wu K, Wang C, Zhang X, Hessien M, Yeung YG, Gioeli D, Weber MJ, and Pestell RG. The Androgen Receptor Acetylation site regulates cAMP and AKT but not ERK-induced activity. Journal of Biological Chemistry. 2004; 279: 29436-29449. PMID: 15123687

Gioeli D, Ficarro SB, Kwiek JJ, Aaronson D, Hancock M, Catling AD, White FM, Christian RE, Settlage RE, Shabanowitz J, Hunt DF, and Weber MJ. Androgen Receptor phosphorylation: regulation and identification of the phosphorylation Sites. Journal of Biological Chemistry. 2002; 277: 29304-29314. PMID: 12015328

Gioeli D, Mandell JW, Frierson HF, Petroni GR, and Weber MJ. Activation of Mitogen-Activated Protein Kinase associated with prostate cancer progression. Cancer Research. 1999; 59(2): 279-284. PMID: 9927031

PubMed Listings for Dan Gioeli