Investigating signal transduction pathways and cancer progression
My primary research interest has focused on the mechanistic underpinnings of how signal transduction pathways cross-talk and contribute to cancer progression, with specific emphasis on identifying and understanding the nodes within the cell signaling network that cause cancer progression and resistance to therapy. We are pursuing three major research projects. The first focuses on the androgen receptor (AR), an established signaling node in prostate cancer. We are studying the molecular mechanisms of AR activity with a specific emphasis on how AR phosphorylation regulates AR function. In our second research project, we are studying kinases that we recently identified through an RNAi screen to identify kinases that regulate prostate cancer cell growth with the goal of uncovering kinase cascades that can overcome the compensatory signaling mechanisms that limit the effectiveness of androgen ablation therapy. The third research project goal is to develop paradigms for the rational design of drug combinations.