Reproductive biology encompasses the cellular and molecular biology, physiology, and regulation of the reproductive systems in both males and females, as well as the events of fertilization that follow the maturation of sperm and eggs. Research in reproductive biology is essential to understanding and influencing both the continuing growth of the world’s population and the infertility that affects significant numbers of couples. Research in reproductive biology in the Department of Cell Biology especially emphasizes fundamentals of reproduction in the male, sperm-oocyte interactions leading to fertilization, and central control of reproductive processes. Our investigators stress the application of contemporary approaches in molecular biology, cell biology, immunology, proteomics, electrophysiology, and advanced imaging to basic and translational research in reproduction. The faculty’s programs and collaborations address many aspects of sperm cell biology from spermatogenesis in the testis through sperm maturation in the epididymis to subsequent capacitation, cell-cell interactions leading to fertilization, and early embryonic development. These and other essential reproductive processes, in both males and females, are controlled by neuroendocrine mechanisms, which are featured in studies of gene regulation and hormone release in the pituitary gland and central nervous system.