Molecular Genetics and Epigenetics Program Members

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Molecular Genetics and Epigenetics Program Members

Program Leaders

P. Todd Stukenberg, PhD, Program Co-Leader
Professor, Department of Biochemistry and Molecular Genetics
Role of aurora kinases in the G2/M checkpoint and mitosis, and dysfunction in aneuploidy.

James M. Larner, MD, Program Co-Leader
Professor and Chair, Department of Radiation Oncology
Molecular basis of resistance to γ-radiation; development of techniques for target-tissue sensitization to ionizing radiation; development of therapeutic focused ultrasound.

 

Full Program Members

Tarek A. Abbas, PhD
Research Assistant Professor, Department of Biochemistry and Molecular Genetics
Regulation of DNA replication and repair by post-translational modification and proteasome activity.

Roger Abounader, MD, PhD
Associate Professor, Department of Microbiology, Immunology and Cancer Biology
Roles and targeting of c-Met in brain tumors; c-Met/PTEN interactions in gliomas; PTEN/mutant-p53 interactions in gliomas; microRNAs in brain tumors.

Mazhar Adli, PhD
Assistant Professor, Department of Biochemistry and Molecular Genetics

Epigenetics, Epigenomics, Genomics, Chromatin, DNA sequencing, ChIP-Seq, Leukemia

David T. Auble, PhD
Professor, Department of Biochemistry and Molecular Genetics
Chromatin remodeling during sensing and repair of DNA damage.

Stefan Bekiranov, PhD
Assistant Professor, Department of Biochemistry and Molecular Genetics
Developing algorithms for analysis of microarray and sequence data from genomic analysis.

Ann L. Beyer, PhD
Professor, Department of Microbiology, Immunology and Cancer Biology
Basic mechanisms of ribosome biogenesis and RNA processing, potential chemotherapeutic targets.

Daniel J. Burke, PhD
Professor, Department of Biochemistry and Molecular Genetics
Molecular mechanisms of spindle checkpoints and their failure in cancer; yeast-based drug screens.

 

Thao Dang, PhD
Associate Professor, Department of Medicine, Hematology/Oncology
Notch signaling in lung cancer; Notch 3 and the associated gamma secretases as therapeutic targets in lung and other cancers.

Anindya Dutta, PhD
Byrd Professor, Department of Biochemistry and Molecular Genetics
Chromosomal rearrangements in prostate cancer; developing methods for detecting translocations; regulation of cell cycle by microRNAs; genomics of DNA replication.

Jaroslaw Dziegielewski, PhD
Assistant Professor, Department of Radiation Oncology
Signal transduction pathways activated by radiation damage for target tissue sensitization to ionizing radiation.

Daniel R. Foltz, PhD
Assistant Professor, Department of Biochemistry and Molecular Genetics
Mechanism of assembly of centromeric chromatin; role of mitosis-specific histone chaperones in cell cycle progression.

Patrick A. Grant, PhD
Associate Professor, Department of Biochemistry and Molecular Genetics
Mis-regulation of SAGA and SAGA-like chromatin remodeling complexes in cancer.

 

Marie-Louise Hammarskjold, MD, PhD
Professor, Department of Microbiology, Immunology and Cancer Biology
Alternative splicing and export of RNAs in HIV-infected cells; relevance to HIV-associated neoplasms.

David R. Jones, MD
Professor, Department of Surgery
Molecular biological investigations leading to targeted therapies in primary lung cancer.

 

Ming D. Li, PhD
Professor, Department of Psychiatry
Genetic linkage and association analysis to understand how tobacco smokers become addicted and why they cannot quit their smoking habit.

 

Jaime Mata, PhD
Assistant Professor of Radiology, Assistant Director of the Center for HPG MR
Early detection and evaluation of treatment efficacy in animal models of lung cancer using novel MRI contrast agents.

Marty W. Mayo, PhD
Associate Professor, Department of Biochemistry and Molecular Genetics
NFΚB involvement in the suppression of apoptosis in non-small-cell lung cancer and in the epithelial-mesenchymal transition.

Deric Park, MD, PhD
Assistant Professor, Department of Neurosurgery
Differentiation and targeted agents in malignant gliomas; clinical treatment of gliomas and chordomas.

Kwon-Sik Park, PhD
Assistant Professor of Microbiology, Immunology, and Cancer Biology

The cellular and molecular mechanisms of progression and chemo-resistance of lung cancer.

Bryce M. Paschal, PhD
Professor, Department of Biochemistry and Molecular Genetics
Role of the androgen receptor and signal transduction pathways in prostate cancer progression.

William R. Pearson, PhD
Professor, Department of Biochemistry and Molecular Genetics
Identification of protein homologs by developing novel computational algorithms; regulation of GST gene expression.

Benjamin W. Purow, MD
Associate Professor, Department of Neurology
Molecular basis of Notch signaling; potential therapeutic targets for malignant gliomas.

Aaron Quinlan, PhD
Assistant Professor, Public Health Sciences

David Schiff, MD
Professor, Department of Neurology
Clinical trials in brain cancer.

Timothy N. Showalter, MD
Professor, Department of Radiation Oncology
Prostate cancer and radiation therapy.

Jeffrey S. Smith, PhD
Associate Professor, Department of Biochemistry and Molecular Genetics
Role of the NADH-dependent deacetylase, sirtuin, in modulating gene expression in aging and carcinogenesis.

M. Mitchell Smith, PhD
Professor, Department of Microbiology, Immunologya and Cancer Biology
Role of histone tails in replication and maintenance of genome integrity; SNF/SWI complex in chromatin remodeling and interaction with the adenovirus E1A oncoprotein.

P. Todd Stukenberg, PhD
Professor, Department of Biochemistry and Molecular Genetics
Role of aurora kinases in the G2/M checkpoint and mitosis, and dysfunction in aneuploidy.

Sharon Teraoka, PhD
Assistant Professor, Biochemistry and Molecular Genetics

Yuh-Hwa Wang, PhD
Associate Professor, Department of Biochemistry and Molecular Biology
Genome instability in human disease

David Wotton, PhD
Assistant Professor, Department of Biochemistry and Molecular Genetics
Regulation of cell proliferation by the tumor suppressor TGF-β; animal models for prostate cancer.

Hui Zong, PhD
Associate Professor, Department of Microbiology, Immunology, and Cancer Biology
Mouse Genetic Mosaic Modeling of Human Cancers

Associate Program Members

Paul N. Adler, PhD
Professor, Department of Biology
Planar signaling, polarity, and morphogenesis, and derangements during tumorigenesis.

Dan A. Engel, PhD
Professor, Department of Microbiology, Immunology and Cancer Biology
Adenovirus E1A oncogene and its interaction with cellular tumor suppressors (e.g., RB and P300).

Melissa A. Henriksen, PhD
Assistant Professor, Department of Biology
Defining epigenetic controls that contribute to tumorigenesis and cancer stem cell plasticity in neuroblastoma.

James Mandell, MD
Associate Professor, Department of Pathology
Astroglial activity in degenerative and malignant brain tumors.